Acute stress induces visceral hypersensitivity via glucocorticoid receptor-mediated membrane insertion of TRPM8: Involvement of a non-receptor tyrosine kinase Pyk2.,Neurogastroenterology & Motility

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Acute stress induces visceral hypersensitivity via glucocorticoid receptor-mediated membrane insertion of TRPM8: Involvement of a non-receptor tyrosine kinase Pyk2.
Neurogastroenterology & Motility ( IF 3.5 ) Pub Date : 2020-05-11 , DOI: 10.1111/nmo.13877
Qing-Qing Luo ₁ , Bo Wang ₁ , Xin Chen ₁ , Hong-Yi Qiu ₁ , Wen-Ting Li ₁ , Xiu-Juan Yan ₁ , Sheng-Liang Chen ₁

Affiliation

Psychological stress is an important factor for the development and recurrence of irritable bowel syndrome (IBS). The mechanisms underlying stress‐induced visceral hypersensitivity (VH), a key pathophysiological component in IBS, are still incompletely understood. We aimed to test whether transient receptor potential melastatin 8 (TRPM8) participates in acute stress–induced VH.

中文翻译：

急性应激通过糖皮质激素受体介导的 TRPM8 膜插入诱导内脏超敏反应：非受体酪氨酸激酶 Pyk2 的参与。

心理压力是肠易激综合征（IBS）发生和复发的重要因素。压力诱发的内脏超敏反应 (VH) 是 IBS 的关键病理生理学成分，其潜在机制仍未完全了解。我们旨在测试瞬时受体电位 melastatin 8 (TRPM8) 是否参与急性应激诱导的 VH。

更新日期：2020-05-11

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