This study evaluated both telomere length (TL) and micronucleus (MN) as indicators of genome instability in 40 anesthesiologists occupationally exposed to anesthetics and in 40 physicians without occupational exposure to anesthetics who were matched by age, sex, and lifestyle. Blood and buccal samples were collected from both groups at the same period. Anesthetic exposure assessment was performed. The studied groups were assessed regarding relative TL by quantitative polymerase chain reaction and MN by buccal MN assay. Mean trace concentrations of anesthetics were below two parts per million. No significant differences between groups were found for both biomarkers. However, MN frequency was slightly increased (1.9‐fold; p = .094) in the exposed group compared to the control group and in the exposed males (2.4‐fold; p = .090) compared to unexposed males. TL and age showed a significant negative correlation. Anesthetic occupational exposure below recommended levels is not associated with changes in TL and MN in anesthesiologists.

中文翻译：

---

通过端粒长度和微核暴露于麻醉药中的医生评估遗传不稳定性。

这项研究评估了40名职业接触麻醉药的麻醉师和40名未按年龄，性别和生活方式进行职业接触的麻醉师的端粒长度（TL）和微核（MN）作为基因组不稳定性的指标。同时从两组中收集血液和颊样本。进行麻醉暴露评估。通过定量聚合酶链反应评估研究组的相对TL，通过颊MN法评估MN。麻醉剂的平均痕量浓度低于百万分之二。两种生物标志物之间没有发现显着差异。但是，MN频率略有增加（1.9倍；p与对照组相比，暴露组的暴露率为0.094），与未暴露组相比，暴露暴露的男性为（2.4倍; p = .090）。TL和年龄呈显着负相关。低于推荐水平的麻醉剂职业暴露与麻醉医师中TL和MN的变化无关。