Neural crest cells (NCCs) delaminate from the neural tube (NT) and migrate ventrally to generate the trunk peripheral nervous system (PNS). Although several signaling pathways have been identified that steer NCCs once they are on their ventral trajectory, no molecules have been identified that are required for the initial migration between the NT and the dorsal root ganglion. Given the critical role of fibroblast growth factor (FGF) signaling in embryogenesis, we investigated its function in this initial migration.

中文翻译：

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FGF 信号传导是躯干神经嵴细胞的趋化作用和腹侧迁移所必需的。

神经嵴细胞 (NCC) 从神经管 (NT) 分层并向腹侧迁移以生成躯干周围神经系统 (PNS)。尽管已经确定了几种信号通路，一旦它们进入腹侧轨迹就引导 NCC，但尚未确定 NT 和背根神经节之间初始迁移所需的分子。鉴于成纤维细胞生长因子 (FGF) 信号在胚胎发生中的关键作用，我们研究了其在初始迁移中的功能。