The frontonasal ectodermal zone (FEZ) is a signaling center that regulates patterned development of the upper jaw, and Sonic hedgehog (SHH) mediates FEZ activity. Induction of SHH expression in the FEZ results from SHH‐dependent signals from the brain and neural crest cells. Given the role of miRNAs in modulating gene expression, we investigated the extent to which miRNAs regulate SHH expression and FEZ signaling.

中文翻译：

---

miR-199 家族有助于调节颅面发育过程中的声波刺猬表达。

额鼻外胚层区 (FEZ) 是调节上颌图案发育的信号中心，Sonic Hedgehog (SHH) 介导 FEZ 活动。FEZ 中 SHH 表达的诱导源于来自大脑和神经嵴细胞的 SHH 依赖性信号。鉴于 miRNA 在调节基因表达中的作用，我们研究了 miRNA 调节 SHH 表达和 FEZ 信号的程度。