Endosulfan is an organochlorine pesticide (OCP) used in large-scale agriculture for controlling a variety of insects and mites that attack food and non-food crops. Although endosulfan has been listed in the Stockholm Convention as a persistent organic pollutant to be worldwide banned, it is still in use in some countries. Like other OCPs, endosulfan is bioaccumulative, toxic and persistent in the environment. Human unintentional exposure may occur through air inhalation, dietary, skin contact, as well as, via transplacental route and breast feeding. Due to its lipophilic nature, endosulfan is rapidly absorbed into the gastrointestinal tract and bioaccumulates in the fatty tissues. Similar to other OCPs, endosulfan has been classified as an endocrine disrupting chemical (EDC). Endocrine action of endosulfan on development and reproductive function of males has been extensively discussed; however, endosulfan effects on the female reproductive tract have received less attention. This review provides an overview of: i) the fate and levels of endosulfan in the environment and human population, ii) the potential estrogenic properties of endosulfan in vitro and in vivo, iii) its effects on uterine development, and iv) the long-term effects on female fertility and uterine functional differentiation during early gestation.

中文翻译：

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产后暴露于硫丹会影响子宫发育和生育能力。

硫丹是一种有机氯农药（OCP），用于大规模农业中，用于控制各种攻击粮食和非粮食作物的昆虫和螨虫。尽管硫丹已在《斯德哥尔摩公约》中列为持久性有机污染物，已在全球范围内被禁止，但在某些国家仍在使用。与其他OCP一样，硫丹在环境中具有生物蓄积性，毒性和持久性。人体的无意暴露可能通过空气吸入，饮食，皮肤接触以及经胎盘途径和母乳喂养发生。由于其亲脂性，硫丹会迅速吸收到胃肠道中并在脂肪组织中生物蓄积。与其他OCP相似，硫丹也被归类为内分泌干扰物（EDC）。硫丹对雄性发育和生殖功能的内分泌作用已得到广泛讨论。然而，硫丹对女性生殖道的影响受到的关注较少。这篇综述概述了：i）硫丹在环境和人类中的命运和水平，ii）硫丹在体外和体内的潜在雌激素特性，iii）硫丹对子宫发育的影响，iv）长期-妊娠早期对女性生育力和子宫功能分化的长期影响。