OBJECTIVES Patients with Crohn's disease often produce antibodies against flagellated intestinal bacteria. There are mixed data as to whether such antibodies are present in patients with spondyloarthritis. Our objectives were to evaluate for the presence of antibodies against intestinal organisms in children with enthesitis related arthritis (ERA). METHODS Children with ERA and healthy controls were recruited at three sites. Sera were plated on a nitrocellulose array and incubated with labelled antibodies to human IgA and IgG. RESULTS At UAB, patients and controls had similar antibody levels against the majority of the bacteria selected, with the exception of increased IgA antibodies among ERA patients against Prevotella oralis (1231 [IQR 750, 2566] versus 706 [IQR 428, 1106], p = .007.) These findings were partially validated at a second but not at a third site. CONCLUSIONS ERA patients may produce increased IgA antibodies against P. oralis. The possible significance of this finding bears further exploration.

中文翻译：

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鉴定口鼻小肠病毒是与脑炎相关的关节炎儿童的可能靶抗原。

目的克罗恩病患者通常会产生针对鞭毛状肠细菌的抗体。关于脊椎关节炎患者中是否存在此类抗体，存在多种数据。我们的目标是评估在患有脑炎相关关节炎（ERA）的儿童中是否存在针对肠道菌的抗体。方法在三个地点招募患有ERA和健康对照的儿童。将血清铺在硝酸纤维素阵列上，并与针对人IgA和IgG的标记抗体一起孵育。结果在UAB，患者和对照者对大多数所选细菌的抗体水平相近，但ERA患者中针对口头波氏杆菌的IgA抗体有所增加（1231 [IQR 750，2566]与706 [IQR 428，1106]，p = .007。）这些发现在第二个站点得到了部分验证，但在第三个站点没有得到验证。结论ERA患者可能产生针对口头疟原虫的IgA抗体增加。这一发现的可能意义有待进一步探索。