A series of commercially available chiral amino-phosphines, in combination with Mn(CO)₅Br, has been evaluated for the asymmetric reduction of ketones, using isopropanol as hydrogen source. With the most selective ligand, the corresponding manganese complex was synthesized and fully characterized. A series of ketones (20 examples) was hydrogenated in the presence of 0.5 mol% of the manganese pre-catalyst at 30 °C, affording the chiral alcohols in high yields with enantiomeric excesses up to 99%.

中文翻译：

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二齿氨基膦负载的锰（I）预催化剂促进的酮的不对称转移加氢

使用异丙醇作为氢源，已评估了一系列与Mn（CO）₅ Br组合使用的手性氨基膦类化合物的酮的不对称还原。用最具选择性的配体合成了相应的锰配合物并进行了充分表征。将一系列酮（20个实例）在0.5摩尔％的锰预催化剂存在下于30°C氢化，以高收率得到手性醇，对映体过量最高可达99％。