Among available methods, supercritical fluid (SCF) technology is a new and suitable approach for producing nano-sized particles. For this purpose, determination of a solid solute solubility such as pharmaceutical materials is an essential step. The present research is the first to measure Tamsulosin (TML) solubility in supercritical carbon dioxide (SC-CO₂) under operating conditions of 308 to 338 K and 12 to 27 MPa. The mole fraction of TML ranged from 0.18 × 10⁻⁶ to 1.013 × 10⁻⁵. Experimental data have been modeled with two main models groups; the first group consisted of semi-empirical and empirical models (e.g., Chrastil; Sodeifian et al.; Kumar & Johnston (K-J); Méndez-Santiago & Teja (MST); Bian et al.; Bartle et al.) and the second group have been SAFT-VR (statistical associating fluid theory of variable range) and Peng-Robinson (PR) equations of state. Furthermore, self-consistency test of the experimental data was performed on the solubility data. Finally, the approximate values ${\Delta H}_{total}$, ${\Delta H}_{vap}$ and ${\Delta H}_{sol}$ enthalpies have been computed.

在许多可用方法中，超临界流体（SCF）技术是一种新的，适合生产纳米级颗粒的方法。为此，确定固体溶质溶解度（例如药物材料）是必不可少的步骤。本研究是首次在308至338 K和12至27 MPa的操作条件下测量坦索罗辛（TML）在超临界二氧化碳（SC-CO ₂）中的溶解度。TML的摩尔分数为0.18×10 ^-6至1.013×10 ^-5。实验数据已通过两个主要模型组进行建模。第一组包括半经验模型和经验模型（例如，Chrastil； Sodeifian等； Kumar＆Johnston（KJ）；Méndez-Santiago＆Teja（MST）； Bian等； Bartle等）。一组是SAFT-VR（可变范围统计缔合流体理论）和Peng-Robinson（PR）状态方程。此外，对溶解度数据进行了实验数据的自洽测试。最后，近似值${\Delta H}_{ŤØŤ\mathrm{一种}升}$， ${\Delta H}_{v\mathrm{一种}p}$ 和 ${\Delta H}_{sØ升}$ 焓已经计算出来。