Mycobacterium tuberculosis (M. tb) is the causative agent of TB and its incidences has been on the rise since 1993. Lipid metabolism is an imperative metabolic process, which grants M. tb the ability to utilize host-derived lipids as a secondary source of nutrition during infection. In addition to degrading host lipids, M. tb is proficient at using lipids, such as cholesterol, to facilitate its entry into macrophages. Mycolic acids, constituents of the mycobacterial cell wall, offer protection and aid in persistence of the bacterium. These are effectively synthesized using a complex fatty acid synthase system. Many pathogenesis studies have reported differences in lipid-metabolism of clinical strains of M. tb that belongs to diverse lineages of the Mycobacterium tuberculosis complex (MTBC). East-Asian and Euro-American lineages possess "unique" cell wall-associated lipids compared to the less transmissible Ethiopian lineage, which may offer these lineages a competitive advantage. Therefore, it is crucial to comprehend the complexities among the MTBC lineages with lipid metabolism and their impact on virulence, transmissibility and pathogenesis. Thus, this review provides an insight into lipid metabolism in various lineages of the MTBC and their impact on virulence and persistence during infection, as this may provide critical insight into developing novel therapeutics to combat TB.

中文翻译：

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脂质代谢的谱系特异性差异及其对结核分枝杆菌临床菌株的影响。

结核分枝杆菌（结核分枝杆菌）是结核的病原体，自1993年以来其发病率一直在上升。脂质代谢是一种必不可少的代谢过程，它使结核分枝杆菌能够利用宿主来源的脂质作为第二代结核病的来源。感染期间的营养。除降解宿主脂质外，结核分枝杆菌还擅长使用脂质（例如胆固醇）来促进其进入巨噬细胞。分枝杆菌细胞壁的组成物质分枝酸提供保护作用，并有助于细菌的持久性。这些是使用复杂的脂肪酸合酶系统有效合成的。许多发病机理研究已经报告了结核分枝杆菌复合物（MTBC）的不同谱系的临床分枝杆菌结核分枝杆菌的脂质代谢差异。东亚和欧美裔拥有“ 传染性和发病机理。因此，本综述提供了对MTBC不同谱系中脂质代谢及其对感染过程中毒力和持久性的影响的见解，因为这可能为开发抗结核新疗法提供了关键见解。传染性和发病机理。因此，本综述提供了对MTBC不同谱系中脂质代谢及其对感染过程中毒力和持久性的影响的见解，因为这可能为开发抗结核新疗法提供了关键见解。