Over the past 50 years, fungal natural products have revolutionized medicine, yielding drugs which have enormous therapeutic potential. The aim of this study was to investigate the probable effect of marine fungal natural products on various skin pathogens. Initially, seventy natural extracts obtained from 35 different marine fungal strains were analysed by the agar well diffusion and broth micro dilution assay for their antibacterial action against six human skin pathogens. The minimum inhibitory effects of all active fungal methanolic extracts on targeted pathogens were observed between 90 and 99% at the concentration of 1 mg/mL. The highest activity was recorded by fungal strains belonging to genera Penicillium, Emericellopsis and Simplicillium. Thereafter, possible effects on target bacterial cells were studied by scanning electron microscopy which show significant destruction and structural deformation in the bacterial cell wall. The results of the present study provided good evidence that the studied marine fungi can be a potential source of natural antibacterial agents against skin bacterial pathogens.

中文翻译：

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海洋真菌代谢产物在致病细菌细胞中的结构变形：一项体外研究。

在过去的50年中，真菌天然产物彻底改变了医学，产生了具有巨大治疗潜力的药物。这项研究的目的是调查海洋真菌天然产物对各种皮肤病原体的可能作用。最初，通过琼脂孔扩散和肉汤微量稀释法分析了从35种不同海洋真菌菌株中提取的70种天然提取物，以分析它们对6种人类皮肤病原体的抗菌作用。在1 mg / mL的浓度下，观察到所有活性真菌甲醇提取物对目标病原体的最小抑制作用在90％至99％之间。最高活性是由属于青霉属，美属拟南芥属和Simplicillium属的真菌菌株记录的。之后，通过扫描电子显微镜研究了可能对靶细菌细胞产生的影响，显示了细菌细胞壁的明显破坏和结构变形。本研究的结果提供了良好的证据，表明所研究的海洋真菌可能是对抗皮肤细菌病原体的天然抗菌剂的潜在来源。