The global pandemic of COVID-19 caused by SARS-CoV-2 (also known as 2019-nCoV and HCoV-19) has posed serious threats to public health and economic stability worldwide, thus calling for development of vaccines against SARS-CoV-2 and other emerging and reemerging coronaviruses. Since SARS-CoV-2 and SARS-CoV have high similarity of their genomic sequences and share the same cellular receptor (ACE2), it is essential to learn the lessons and experiences from the development of SARS-CoV vaccines for the development of SARS-CoV-2 vaccines. In this review, we summarized the current knowledge on the advantages and disadvantages of the SARS-CoV vaccine candidates and prospected the strategies for the development of safe, effective and broad-spectrum coronavirus vaccines for prevention of infection by currently circulating SARS-CoV-2 and other emerging and reemerging coronaviruses that may cause future epidemics or pandemics.

由 SARS-CoV-2（也称为 2019-nCoV 和 HCoV-19）引起的 COVID-19 全球大流行对全球公共卫生和经济稳定构成了严重威胁，因此需要开发针对 SARS-CoV-2 的疫苗以及其他新出现和重新出现的冠状病毒。由于SARS-CoV-2和SARS-CoV基因组序列高度相似，并且具有相同的细胞受体（ACE2），因此有必要吸取SARS-CoV疫苗研发的教训和经验，对SARS-CoV的研发至关重要。 CoV-2 疫苗。在这篇综述中，我们总结了目前对 SARS-CoV 候选疫苗优缺点的认识，并展望了开发安全、有效和广谱的冠状病毒疫苗以预防当前流行的 SARS-CoV-2 感染的策略以及其他可能导致未来流行病或大流行的新出现和重新出现的冠状病毒。