Characterization of the Th17 profile immune response in cases of human rabies transmitted by dogs and its interference in the disease pathogenesis.,Journal of Neuroimmunology

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Characterization of the Th17 profile immune response in cases of human rabies transmitted by dogs and its interference in the disease pathogenesis.
Journal of Neuroimmunology ( IF 2.9 ) Pub Date : 2020-07-01 , DOI: 10.1016/j.jneuroim.2020.577263
L B Santos ₁ , F Guedes ₁ , S M Achkar ₁ , M I S Duarte ₂ , I S S Katz ₁ , S R Silva ₁ , E R Fernandes ₁

Affiliation

The Th17 profile immune response is influenced by the presence of cytokines such as IL-1, IL-6, TGF-β, IL-17, and IL-23. We sought to characterize the Th17 profile in CNS samples from human rabies cases transmitted by dogs and examine its possible influence on disease pathogenesis. We observed a high expression of TGF-β, followed by IL-23, IL-17 and IL-6, and a low expression of IL-1β and IFN-γ. Those results suggest the participation of Th17 in rabies virus neuroinfection transmitted by dogs. IL-23 probably plays a role in maintaining the Th17 profile, but it can also interfere with the establishment of the Th1 profile and viral clearance.

中文翻译：

狗传播的人类狂犬病病例中 Th17 谱免疫反应的表征及其对疾病发病机制的干扰。

Th17 谱免疫反应受细胞因子的影响，如 IL-1、IL-6、TGF-β、IL-17 和 IL-23。我们试图表征由狗传播的人类狂犬病病例的 CNS 样本中的 Th17 谱，并检查其对疾病发病机制的可能影响。我们观察到 TGF-β 的高表达，其次是 IL-23、IL-17 和 IL-6，以及 IL-1β 和 IFN-γ 的低表达。这些结果表明 Th17 参与了狗传播的狂犬病病毒神经感染。IL-23 可能在维持 Th17 谱中起作用，但它也会干扰 Th1 谱的建立和病毒清除。

更新日期：2020-07-01

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