The reaction of methyl ester C-11, C-15 bis-TBDPS derivative of cloprostenol with DAST in CH₂Cl₂ at −78 °C followed by warming to room temperature results in a product of S_N2-substitution at C-9, elimination to give a Δ^8,9-olefine, and epimeric 9-deoxy-C-8 fluorides. The reaction products were separated by TLC and HPLC methods. After unblocking the TBDPS protective groups, the antiaggregatory and uterotonic properties of the resulting compounds were studied.

中文翻译：

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含氟氯丁烯醇的类似物

氯前列醇的甲酯C-11，C-15氯丁烯醇的C15双-TBDPS衍生物与DAST在CH ₂ Cl _2中于-78°C反应，然后升温至室温，在C-9处生成S _N 2-取代的产物消除，得到△ ^8，9-烯烃和差向异构的9-脱氧-C-8氟化物。通过TLC和HPLC方法分离反应产物。解开TBDPS保护基团后，研究了所得化合物的抗聚集和子宫收缩性质。