OBJECTIVE To investigate the effect of paternal body mass index (BMI) on neonatal outcomes of singletons after frozen-thawed embryo transfer (FET) cycles. DESIGN Retrospective cohort study. SETTING Tertiary-care academic medical center. PATIENT(S) A total of 7,908 singleton newborns were divided into four categories based on their paternal BMI: 284 (3.6%) infants were in the paternal underweight category, 4,678 (59.2%) infants were in the paternal normal weight category, 2,585 (32.7%) infants were in the paternal overweight category, and 361 (4.6%) infants were in the paternal obesity category. In addition, we included only infants of women with normal BMI (18.5 kg/m2 ≤ BMI < 25 kg/m2). INTERVENTION(S) None. MAIN OUTCOME MEASURE(S) Neonatal outcomes. RESULT(S) The rates of large for gestational age (LGA) infants were significantly higher among those in the paternal overweight and obesity categories than those in the paternal underweight categories. The rates of very LGA were higher among infants in the paternal overweight categories and lower among infants in the paternal underweight categories than the rates in normal controls. The rates of fetal macrosomia were higher among infants in the paternal overweight categories than among infants in the paternal normal weight categories. Compared with normal controls, Z-scores (gestational age- and sex-adjusted birthweight) were significantly higher among the infants in the paternal overweight and paternal obesity categories and significantly lower among the infants in the paternal underweight categories. A positive association was observed in a multiple linear regression model between paternal BMI and newborn birthweights after adjustment for several potential confounders. CONCLUSION(S) Paternal BMI had an independent impact on the birthweight of singletons born after FET cycles. Paternal overweight and paternal obesity were independent risk factors for having LGA infants after FET cycles. Furthermore, paternal overweight was an independent risk factor for fathering infants with macrosomia or very LGA infants after FET cycles.

中文翻译：

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父亲体重指数对冻融胚胎移植周期后单胎新生儿结局的影响：对 7,908 名单胎新生儿的分析

目的 研究父亲体重指数 (BMI) 对冻融胚胎移植 (FET) 周期后单胎新生儿结局的影响。设计 回顾性队列研究。设置三级护理学术医疗中心。患者 共有 7,908 名单胎新生儿根据其父亲的 BMI 分为四类：284 (3.6%) 名婴儿属于父亲体重不足类别，4,678 (59.2%) 名婴儿属于父亲正常体重类别，2,585 ( 32.7%) 的婴儿属于父亲超重类别，361 (4.6%) 名婴儿属于父亲肥胖类别。此外，我们仅纳入了 BMI 正常（18.5 kg/m2 ≤ BMI < 25 kg/m2）女性的婴儿。干预措施 无。主要结局指标 新生儿结局。结果 在父亲超重和肥胖类别中，大于胎龄 (LGA) 婴儿的发生率显着高于父亲体重过轻类别。与正常对照组相比，父亲超重类别婴儿的极 LGA 发生率较高，而父亲体重过轻类别婴儿的极 LGA 发生率较低。父亲超重类别婴儿的巨大胎儿率高于父亲体重正常类别婴儿。与正常对照相比，父亲超重和父亲肥胖类别婴儿的 Z 分数（胎龄和性别调整出生体重）显着较高，而父亲体重不足类别婴儿的 Z 分数显着较低。在调整了几个潜在的混杂因素后，在父亲 BMI 和新生儿出生体重之间的多元线性回归模型中观察到正相关。结论 (S) 父亲 BMI 对 FET 周期后出生的单胎出生体重有独立影响。父亲超重和父亲肥胖是 FET 周期后 LGA 婴儿的独立危险因素。此外，父亲超重是父亲在 FET 周期后巨大儿或非常 LGA 婴儿的独立危险因素。父亲超重和父亲肥胖是 FET 周期后 LGA 婴儿的独立危险因素。此外，父亲超重是父亲在 FET 周期后巨大儿或非常 LGA 婴儿的独立危险因素。父亲超重和父亲肥胖是 FET 周期后 LGA 婴儿的独立危险因素。此外，父亲超重是父亲在 FET 周期后巨大儿或非常 LGA 婴儿的独立危险因素。