Interactions between germinal center B cells and immune cells in the microenvironment can play integral roles in transformation and growth of follicular lymphoma (FL). Three recent studies, two in this issue of Cancer Cell and one in Cell Reports, elucidate how genetic alterations in CTSS and EZH2 impact these interactions, with implications for FL immunotherapy.

中文翻译：

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遗传改变影响滤泡性淋巴瘤中的免疫微环境相互作用。

微环境中生发中心B细胞和免疫细胞之间的相互作用可以在滤泡性淋巴瘤（FL）的转化和生长中发挥不可或缺的作用。最近的三项研究阐明了CTSS和EZH2的遗传改变如何影响这些相互作用，从而对FL免疫疗法产生了影响，两项研究在本期《癌细胞》杂志上发表，另一篇在细胞报告中。