Filamentous fungi are important industrial cell factories used for the production of a wide range of enzymes and metabolites. Their primary metabolism is a significant source of industrially important compounds, as well as of monomeric building blocks for the production of secondary metabolites and extracellular enzymes. Therefore, large efforts have been made towards the development of suitable strains for the industrial scale production of primary metabolites. Over the last decades, metabolic engineering of primary metabolism has become a powerful tool to enhance production of both primary and secondary metabolites. This review summarises the different metabolic engineering methods that have been applied to rationally improve the production of industrially relevant primary metabolites in filamentous fungi, and discusses related challenges and future perspectives.

丝状真菌是重要的工业细胞工厂，用于生产各种酶和代谢产物。它们的主要代谢是工业上重要化合物以及产生次级代谢产物和细胞外酶的单体结构的重要来源。因此，为开发适合工业规模生产初级代谢产物的菌株已做出了巨大的努力。在过去的几十年中，初级代谢的代谢工程已成为增强初级和次级代谢产物产生的有力工具。这篇综述总结了已被用来合理改善丝状真菌中与工业相关的主要代谢产物生产的不同代谢工程方法，