A study of the ¹⁰B-enriched Boronophenylalanine-fructose complex(¹⁰BPA-F) infusion procedure in potential BNCT patients, including three skin melanomas of extremities, was performed. ¹⁰B concentration in tumor(T), blood(B), skin(S) were measured to determine tumor/blood(T/B) and skin/blood(S/B) ratios. T/B ratio for three melanoma patients was in the range 1.48-3.82(average 2.56 ± 0.69). S/B ratio was in the range 0.81-1.99(average 1.29 ± 0.35). Results showed that T/B ratio of nodular metastasis melanoma was higher than superficial spreading melanoma. ¹⁰B concentration in skin was higher than blood, which was helpful to avoid over-dose in normal skin.

所述的研究¹⁰ B-富含硼-苯丙氨酸-果糖复合物（¹⁰ BPA-F）中电位BNCT患者注射过程，包括四肢的三种皮肤黑素瘤，进行。测量肿瘤(T)、血液(B)、皮肤(S)中的¹⁰ B浓度以确定肿瘤/血液(T/B)和皮肤/血液(S/B)比率。三名黑色素瘤患者的 T/B 比在 1.48-3.82（平均 2.56 ± 0.69）范围内。S/B 比在 0.81-1.99 范围内（平均 1.29 ± 0.35）。结果显示结节性转移黑色素瘤的T/B比高于浅表扩散黑色素瘤。¹⁰ B在皮肤中的浓度高于血液，有助于避免正常皮肤过量服用。