PURPOSE Previously, brain volume (BV) and intracranial cerebrospinal fluid volume (CSFV) have been investigated regarding clinical outcomes of subgroups of ischemic stroke patients. This study aimed to examine if the preexisting, preischemic BV and CSFV have an impact on good functional outcome and mortality in acute ischemic stroke (AIS) patients treated with mechanical thrombectomy (MT). METHODS Preischemic BV, CSFV, and CSFV/Total intracranial volume (TICV)-ratio were calculated with a fully automated segmentation platform. Univariate and multivariate analyses were used to study associations. RESULTS In this retrospective study 107 subsequent AIS patients of a prospective database were included. The segmentation results of the fully automated algorithm based on non-contrast computerized tomography scans (NCCT) correlated significantly with the segmentation results obtained from 3D T1 weighted magnetic resonance images (P < 0.001). In the univariate analysis a preexisting BV (P < 0.001), preexisting CSFV (P = 0.009), and the ratio CSFV/total intracranial volume (P < 0.001) each significantly correlated with good functional outcome and mortality. However, in the multivariate regression analysis, also correcting for patient age, none of these volumes remained to correlate with these outcome parameters. CONCLUSION In summary, an association of BV, CSFV, and the CSFV/TICV-ratio with good functional outcome and mortality in AIS treated with MT could not be established. A fully automated segmentation algorithm based on NCCT was successfully developed in-house for calculating the volumes of interest.

中文翻译：

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脑容量和颅内脑脊液容量对接受血管内治疗的中风患者临床结局的影响。

目的以前，已经对缺血性中风患者亚组的临床结局进行了脑容量（BV）和颅内脑脊髓液容量（CSFV）的研究。这项研究的目的是检查在机械性血栓切除术（MT）治疗的急性缺血性卒中（AIS）患者中，先前存在的缺血前BV和CSFV是否对良好的功能结局和死亡率产生影响。方法采用全自动分割平台计算缺血前BV，CSFV和CSFV /颅内总体积（TICV）的比率。单变量和多变量分析用于研究关联。结果在这项回顾性研究中，纳入了107名具有前瞻性数据库的AIS患者。基于无对比计算机断层扫描（NCCT）的全自动算法的分割结果与从3D T1加权磁共振图像获得的分割结果显着相关（P <0.001）。在单变量分析中，预先存在的BV（P <0.001），先前存在的CSFV（P = 0.009）和CSFV /颅内总体积之比（P <0.001）均与良好的功能预后和死亡率显着相关。但是，在多变量回归分析中（也针对患者年龄进行校正），这些量中没有一个与这些结局参数相关。结论总的来说，尚不能建立BV，CSFV和CSFV / TICV比值与MT治疗的AIS的良好功能预后和死亡率相关。