Background. Spontaneous recovery early after stroke is most evident during a time-sensitive window of heightened neuroplasticity, known as spontaneous neurobiological recovery. It is unknown whether poststroke upper-limb motor and somatosensory impairment both reflect spontaneous neurobiological recovery or if somatosensory impairment and/or recovery influences motor recovery. Methods. Motor (Fugl-Meyer upper-extremity [FM-UE]) and somatosensory impairments (Erasmus modification of the Nottingham Sensory Assessment [EmNSA-UE]) were measured in 215 patients within 3 weeks and at 5, 12, and 26 weeks after a first-ever ischemic stroke. The longitudinal association between FM-UE and EmNSA-UE was examined in patients with motor and somatosensory impairments (FM-UE ≤ 60 and EmNSA-UE ≤ 37) at baseline. Results. A total of 94 patients were included in the longitudinal analysis. EmNSA-UE increased significantly up to 12 weeks poststroke. The longitudinal association between motor and somatosensory impairment disappeared when correcting for progress of time and was not significantly different for patients with severe baseline somatosensory impairment. Patients with a FM-UE score ≥18 at 26 weeks (n = 55) showed a significant positive association between motor and somatosensory impairments, irrespective of progress of time. Conclusions. Progress of time, as a reflection of spontaneous neurobiological recovery, is an important factor that drives recovery of upper-limb motor as well as somatosensory impairments in the first 12 weeks poststroke. Severe somatosensory impairment at baseline does not directly compromise motor recovery. The study rather suggests that spontaneous recovery of somatosensory impairment is a prerequisite for full motor recovery of the upper paretic limb.

中文翻译：

---

体感障碍的恢复是否是中风后早期上肢运动恢复的条件？


背景。中风后早期的自发恢复在神经可塑性增强的时间敏感窗口期间最为明显，称为自发神经生物学恢复。目前尚不清楚中风后上肢运动和体感障碍是否都反映了自发的神经生物学恢复，或者体感障碍和/或恢复是否影响运动恢复。方法。在 3 周内以及术后 5、12 和 26 周对 215 名患者进行了运动（Fugl-Meyer 上肢 [FM-UE]）和躯体感觉障碍（诺丁汉感觉评估的伊拉斯谟修改版 [EmNSA-UE]）的测量。有史以来第一次缺血性中风。在基线时有运动和体感障碍（FM-UE ≤ 60 和 EmNSA-UE ≤ 37）的患者中检查了 FM-UE 和 EmNSA-UE 之间的纵向关联。结果。纵向分析共有 94 名患者。 EmNSA-UE 在中风后 12 周内显着增加。当校正时间进展时，运动和体感障碍之间的纵向关联消失，并且对于基线严重体感障碍的患者没有显着差异。 26 周时 FM-UE 评分≥18 的患者 (n = 55) 显示出运动和躯体感觉障碍之间存在显着的正相关，而与时间的进展无关。结论。时间的进展作为自发神经生物学恢复的反映，是推动中风后前 12 周内上肢运动和体感障碍恢复的重要因素。基线时严重的体感障碍不会直接影响运动恢复。该研究表明，体感障碍的自发恢复是上肢瘫痪完全运动恢复的先决条件。