INTRODUCTION Assessing the benefit of cognitive rehabilitation (CR) remains difficult. METHOD An observational study was conducted in 33 patients with early-stage Alzheimer disease and their caregiver included in a clinical CR program at home, compared to 17 patients who received usual treatment. Evaluation of patient's dependence and objective and subjective caregiver's burden was performed by the caregiver with a research tool focusing on impairment in daily activities related to cognitive deficits. RESULTS Repeated measures analysis of variance showed a time by group interaction (P < .05), with decreased patient's dependence for adapted activities at 1 year in the CR group. Lawton scale for daily activities showed also a time by group interaction (P < .05), with increased dependence at 1 year in the control group. There was a significant decrease in Mini-Mental State Examination scores in both groups at 1-year follow-up (P < .05). Concerning caregiver's subjective burden, there was a trend for the time by group interaction (P = .07), and post hoc Tukey test showed that subjective burden was decreased in the CR group (P < .05). This was confirmed by nonparametric Mann-Whitney analysis on differences between follow-up and baseline evaluation (P < .05). CONCLUSION This observational study in a clinical setting is in line with the benefit of CR reported in recent randomized controlled trials. The benefit obtained for adapted daily activities remained after 1 year, even if global cognition declined. Moreover, caregiver's subjective burden related to all relevant daily activities evaluated within the CR program was decreased after 1 year in our clinical setting.

中文翻译：

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认知康复与通常在家中治疗阿尔茨海默病早期患者的疗效。

介绍 评估认知康复 (CR) 的益处仍然很困难。方法 一项观察性研究在 33 名早期阿尔茨海默病患者及其家庭临床 CR 计划中的照顾者中进行，与 17 名接受常规治疗的患者进行比较。护理人员使用研究工具对患者的依赖性以及客观和主观护理人员的负担进行评估，该工具侧重于与认知缺陷相关的日常活动的损害。结果 重复测量方差分析显示，组间相互作用的时间（P < .05），在 CR 组中，患者在 1 年时对适应活动的依赖性降低。日常活动的劳顿量表也显示了按组互动的时间（P < .05），对照组在 1 年时依赖性增加。随访 1 年时，两组的简易精神状态检查得分均显着降低（P < .05）。关于看护者的主观负担，分组互动时间有趋势（P = .07），事后 Tukey 检验显示 CR 组主观负担降低（P < .05）。对随访和基线评估之间差异的非参数 Mann-Whitney 分析证实了这一点（P < .05）。结论 这项临床观察性研究与近期随机对照试验中报告的 CR 益处一致。即使全球认知下降，适应日常活动所获得的好处在 1 年后仍然存在。此外，照顾者'