CRISPR base editors can induce single-base-pair changes in the genome, although they are often inefficient. A study now shows that fusion of the DNA-binding domain of RAD51 to base editors enhances both the efficiency and the targeting range of optimized enzymes. These ‘hyper-editors’ offer effective tools for disease modeling and gene therapy.

中文翻译：

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基本编辑进入超级驱动器。

CRISPR碱基编辑器可以诱导基因组中的单碱基对改变，尽管它们通常效率低下。现在的一项研究表明，RAD51的DNA结合结构域与碱基编辑器的融合提高了优化酶的效率和靶向范围。这些“超级编辑”为疾病建模和基因治疗提供了有效的工具。