Methionine hydroxy analogue (MHA) has been widely used and shows positive effects on growth in poultry, swine, ruminant and aquatic animals. Nevertheless, the utilization efficiency of methionine hydroxy analogue remains controversial considering the wide variation in effects across studies, feeding parameters and environmental culture conditions. Meta‐analysis can quantify the effect of adding MHA on animal performance. Here, we analysed the effect of MHA‐supplemented diets on the final weight (FW), per cent weight gain (WG), protein efficiency ratio (PER), feed conversion ratio (FCR) and feed efficiency (FE) in common, diverse aquaculture taxa. To conduct the meta‐analyses, twenty‐three published studies were included that accounted for 249 effect sizes estimated across eight fish and one shrimp species. The effect size (measured as the standardized mean difference; Hedges’ g) of response parameters between MHA level in a diet formulation and an MHA‐less control condition was calculated. Based on these results, adding MHA in the diet can significantly improve FW, WG, PER, and FE and decrease FCR for fish rather than shrimp. Using meta‐regression analysis, there was a significant quadratic linear relationship between MHA addition and effect size for FW (P = 0.002 for MHA, P = 0.042 for MHA²), and significant linear relationships between MHA addition and effect size for WG (P = 0.0005) and FCR (P = 0.002). There was no significant relationship, linear or non‐linear, between the MHA addition and effect size for FE (P = 0.985) and PER (P = 0.461). In all, when properly dosed in diets, MHA can significantly improve aquaculture production for fish.

中文翻译：

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应用荟萃分析了解日粮中添加蛋氨酸羟基类似物对鱼虾生长性能和饲料利用率的影响

蛋氨酸羟基类似物（MHA）已被广泛使用，并显示出对家禽，猪，反刍动物和水生动物生长的积极影响。然而，考虑到跨研究，进食参数和环境培养条件的影响差异很大，蛋氨酸羟基类似物的利用效率仍存在争议。荟萃分析可以量化添加MHA对动物生产性能的影响。在这里，我们分析了补充了MHA的日粮对最终体重（FW），体重增加百分比（WG），蛋白质效率比（PER），饲料转化率（FCR）和饲料效率（FE）的影响，水产养殖分类群。为了进行荟萃分析，纳入了23项已发表的研究，这些研究估计了8种鱼类和一种虾类的249种效应大小。g）计算了日粮配方中MHA水平与无MHA对照条件之间的响应参数。根据这些结果，在饮食中添加MHA可以显着改善鱼类而不是虾的FW，WG，PER和FE，并降低FCR。使用荟萃回归分析，FHA的MHA添加与效应大小之间存在显着的二次线性关系（MHA的P  = 0.002， MHA ^2具有P = 0.042 ），并且WG的MHA添加与效应大小之间存在显着的线性关系（P  = 0.0005）和FCR（P  = 0.002）。FE（P  = 0.985）和PER（P = 0.985）的MHA添加量与效应量之间没有线性或非线性的显着关系。P  = 0.461）。总而言之，如果适当地按日剂量添加，MHA可以显着提高鱼类的水产养殖产量。