Accuracy and spatial properties of distributed magnetic source imaging techniques in the investigation of focal epilepsy patients.,Human Brain Mapping

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Accuracy and spatial properties of distributed magnetic source imaging techniques in the investigation of focal epilepsy patients.
Human Brain Mapping ( IF 3.5 ) Pub Date : 2020-05-09 , DOI: 10.1002/hbm.24994
Giovanni Pellegrino _{1,

2,

3} , Tanguy Hedrich ₃ , Manuel Porras-Bettancourt ₁ , Jean-Marc Lina _{4,

5} , Ümit Aydin ₆ , Jeffery Hall ₁ , Christophe Grova _{1,

3,

5,

6} , Eliane Kobayashi ₁

Affiliation

Source localization of interictal epileptiform discharges (IEDs) is clinically useful in the presurgical workup of epilepsy patients. We aimed to compare the performance of four different distributed magnetic source imaging (dMSI) approaches: Minimum norm estimate (MNE), dynamic statistical parametric mapping (dSPM), standardized low‐resolution electromagnetic tomography (sLORETA), and coherent maximum entropy on the mean (cMEM). We also evaluated whether a simple average of maps obtained from multiple inverse solutions (Ave) can improve localization accuracy. We analyzed dMSI of 206 IEDs derived from magnetoencephalography recordings in 28 focal epilepsy patients who had a well‐defined focus determined through intracranial EEG (iEEG), epileptogenic MRI lesions or surgical resection. dMSI accuracy and spatial properties were quantitatively estimated as: (a) distance from the epilepsy focus, (b) reproducibility, (c) spatial dispersion (SD), (d) map extension, and (e) effect of thresholding on map properties. Clinical performance was excellent for all methods (median distance from the focus MNE = 2.4 mm; sLORETA = 3.5 mm; cMEM = 3.5 mm; dSPM = 6.8 mm, Ave = 0 mm). Ave showed the lowest distance between the map maximum and epilepsy focus (Dmin lower than cMEM, MNE, and dSPM, p = .021, p = .008, p < .001, respectively). cMEM showed the best spatial features, with lowest SD outside the focus (SD lower than all other methods, p < .001 consistently) and high contrast between the generator and surrounding regions. The average map Ave provided the best localization accuracy, whereas cMEM exhibited the lowest amount of spurious distant activity. dMSI techniques have the potential to significantly improve identification of iEEG targets and to guide surgical planning, especially when multiple methods are combined.

中文翻译：

分布式磁源成像技术在局灶性癫痫患者调查中的准确性和空间特性。

发作间期癫痫样放电 (IED) 的源定位在临床上可用于癫痫患者的术前检查。我们旨在比较四种不同分布式磁源成像 (dMSI) 方法的性能：最小范数估计 (MNE)、动态统计参数映射 (dSPM)、标准化低分辨率电磁断层扫描 (sLORETA) 和均值的相干最大熵(cMEM)。我们还评估了从多个逆解 (Ave) 获得的地图的简单平均值是否可以提高定位精度。我们分析了来自 28 名局灶性癫痫患者的脑磁图记录的 206 个 IED 的 dMSI，这些患者通过颅内 EEG (iEEG)、致痫性 MRI 病变或手术切除确定了明确的病灶。dMSI 准确性和空间特性被定量估计为：（a）距癫痫病灶的距离，（b）可重复性，（c）空间分散（SD），（d）地图扩展，以及（e）阈值对地图特性的影响。所有方法的临床性能都非常出色（距焦点的中位距离 MNE = 2.4 mm；sLORETA = 3.5 mm；cMEM = 3.5 mm；dSPM = 6.8 mm，Ave = 0 mm）。Ave 显示图最大值和癫痫病灶之间的最低距离（Dmin 低于 cMEM、MNE 和 dSPM，p = .021，p = .008，p < .001，分别）。cMEM 显示出最好的空间特征，焦点外的 SD 最低（SD 低于所有其他方法，p < .001 始终如一）和发生器与周围区域之间的高对比度。平均地图 Ave 提供了最好的定位精度，而 cMEM 表现出最低数量的虚假远距离活动。dMSI 技术有可能显着改善 iEEG 目标的识别并指导手术计划，特别是当多种方法结合使用时。

更新日期：2020-07-06

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