Programmable ROS-Mediated Cancer Therapy via Magneto-Inductions.,Advanced Science

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Programmable ROS-Mediated Cancer Therapy via Magneto-Inductions.
Advanced Science ( IF 14.3 ) Pub Date : 2020-05-09 , DOI: 10.1002/advs.201902933
Jiaojiao Wu _{1,

2} , Peng Ning ₁ , Rui Gao ₁ , Qishuai Feng ₁ , Yajing Shen ₁ , Yifan Zhang ₃ , Yingze Li ₁ , Chang Xu ₁ , Yao Qin ₁ , Gustavo R Plaza ₄ , Qianwen Bai ₁ , Xing Fan ₁ , Zhenguang Li ₁ , Yu Han ₅ , Maciej S Lesniak ₅ , Haiming Fan ₃ , Yu Cheng _{1,

2}

Affiliation

Reactive oxygen species (ROS), a group of oxygen derived radicals and derivatives, can induce cancer cell death via elevated oxidative stress. A spatiotemporal approach with safe and deep‐tissue penetration capabilities to elevate the intracellular ROS level is highly desirable for precise cancer treatment. Here, a mechanical‐thermal induction therapy (MTIT) strategy is developed for a programmable increase of ROS levels in cancer cells via assembly of magnetic nanocubes integrated with alternating magnetic fields. The magneto‐based mechanical and thermal stimuli can disrupt the lysosomes, which sequentially induce the dysfunction of mitochondria. Importantly, intracellular ROS concentrations are responsive to the magneto‐triggers and play a key role for synergistic cancer treatment. In vivo experiments reveal the effectiveness of MTIT for efficient eradication of glioma and breast cancer. By remote control of the force and heat using magnetic nanocubes, MTIT is a promising physical approach to trigger the biochemical responses for precise cancer treatment.

中文翻译：

通过磁感应进行可编程 ROS 介导的癌症治疗。

活性氧（ROS）是一组氧衍生的自由基和衍生物，可以通过升高的氧化应激诱导癌细胞死亡。具有安全和深层组织渗透能力来提高细胞内 ROS 水平的时空方法对于精确的癌症治疗来说是非常需要的。在这里，开发了一种机械热感应疗法 (MTIT) 策略，通过组装与交变磁场集成的磁性纳米立方体，以可编程方式增加癌细胞中的 ROS 水平。基于磁的机械和热刺激可以破坏溶酶体，从而导致线粒体功能障碍。重要的是，细胞内 ROS 浓度对磁触发器有反应，在协同癌症治疗中发挥关键作用。体内实验揭示了 MTIT 有效根除神经胶质瘤和乳腺癌的有效性。通过使用磁性纳米立方体远程控制力和热，MTIT 是一种很有前途的物理方法，可以触发生化反应以实现精确的癌症治疗。

更新日期：2020-06-24

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