A systematic study on targeted drug delivery is carried out in an unsteady flow of blood infused with magnetic nanoparticles with an aim to understand the flow pattern and nanoparticle aggregation in a diseased arterial segment having atherosclerosis. The magnetic NPs(nanoparticles) are supervised by a magnetic field, which is significant for the therapeutic treatment of arterial diseases, tumors, and cancer cells and removing blood clots. Coupled thermal energy equation has been modeled by considering the dissipation of energy that encounters due to the application of the magnetic field and the presence of high viscosity of blood. The simulation technique used to solve the mathematical model is vorticity-stream function formulations in the diseased artery. An elevation in SLP (Specific loss power) is noted in the aortic bloodstream when the agglomeration of nanoparticles is higher. This phenomenon has potential applications in the treatment of hyperthermia. The study focuses on the lowering of WSS (wall shear stress) with increasing particle concentration at the downstream of the stenosis, which depicts the vigorous flow circulation zone. These low shear stress regions prolong the residing time of the nanoparticles carrying drugs, which soaks up the LDL (Low-Density Lipoprotein) deposition. Moreover, an increase in NP concentration enhances the Nusselt number, which marks the increase of heat transfer from the arterial wall to the surrounding tissues to destroy tumor and cancer cells without affecting the healthy cells. The results have a significant influence on the study of medicine to treat arterial diseases such as atherosclerosis without the need for surgery, which can minimize the expenditures on cardiovascular treatments and post-surgical complications in patients.

在注入磁性纳米颗粒的不稳定血液中进行了针对药物输送的系统研究，目的是了解具有动脉粥样硬化的病变动脉段的流动模式和纳米颗粒聚集。磁性NP（纳米颗粒）由磁场监管，这对动脉疾病，肿瘤和癌细胞的治疗性治疗以及清除血块具有重要意义。已经通过考虑由于施加磁场和血液的高粘度而遇到的能量耗散来对耦合的热能方程建模。用于求解数学模型的模拟技术是患病动脉中的涡流函数公式。当纳米颗粒的团聚较高时，在主动脉血流中SLP（特定损失功率）升高。该现象在热疗的治疗中具有潜在的应用。该研究的重点是随着狭窄下游颗粒浓度的增加，降低WSS（壁面剪应力），从而描绘出活跃的流动循环区。这些低剪切应力区域延长了携带药物的纳米颗粒的停留时间，从而吸收了LDL（低密度脂蛋白）沉积。此外，NP浓度的增加会增强Nusselt数，这标志着从动脉壁到周围组织的热传递增加，从而破坏了肿瘤和癌细胞而不影响健康细胞。