Azoxystrobin (AZ), pyraclostrobin (PYR) and coumoxystrobin (COU) exert negative impacts on Chlorella vulgaris. Thus, in this study, C. vulgaris was used to assess the respiratory toxicity of AZ, PYR and COU by determining the acute toxicity, complex III activity and ATP viability. The 96 h-EC₅₀ values of AZ, PYR and COU for C. vulgaris were 1.85, 2.21 and 1.62 mg/L, respectively. AZ, PYR and COU exerted significant effects on complex III activity and ATP viability after exposure to 0.71, 1.01 and 1.08 mg/L of the fungicides. The binding potentials of AZ, PYR and COU toward ubiquinone were − 10.44, − 9.31 and − 12.98 kcal/mol, respectively, which had adverse effects on amino acids. These results provided new insight into the potential acute respiratory toxicity mechanisms of these strobilurin fungicides in algae.

中文翻译：

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嘧菌酯，吡菌酯和香豆素对寻常小球藻的呼吸毒性。

嘧菌酯（AZ），吡唑醚菌酯（PYR）和库玛嘧菌酯（COU）对寻常小球藻产生负面影响。因此，在这项研究中，通过测定急性毒性，复合物III活性和ATP活力，使用了C. vulgaris来评估AZ，PYR和COU的呼吸道毒性。寻常棒状梭菌的AZ，PYR和COU的96 h-EC ₅₀值分别为1.85、2.21和1.62 mg / L。AZ，PYR和COU在暴露于0.71、1.01和1.08 mg / L的杀真菌剂后，对复合物III的活性和ATP活力具有显着影响。AZ，PYR和COU与泛醌的结合电位分别为-10.44，-9.31和-12.98 kcal / mol，这对氨基酸有不利影响。这些结果为藻类中这些嗜球果伞素杀菌剂的潜在急性呼吸毒性机制提供了新的认识。