Research has shown that the climate in northwest China has turned to warm-wet in recent decades. Does this mean that the entire northwest of China has become wet in the last few decades? In the context of the climate transition in northwest China, this paper investigates whether the Bosten Lake Basin (BLB) located in southern Xinjiang has been dry or wet in the last 30 years. We used the Standardized Precipitation Evapotranspiration Index (SPEI) and Temperature Vegetation Drought Index (TVDI) to investigate these changes. The results show that although the dry-wet changes indicated by the SPEI and TVDI exhibited slight spatiotemporal differences, the entire BLB reflected a tendency to be dry. That is, the BLB has not become wet during the climate transition in northwest China, but is developing a trend toward aridification. The main conclusions of this study are as follows: (1) The SPEI indicated a drying trend in seasonal and interannual variations in plains; in mountains, except in spring and summer it has a drying trend, too. (2) The TVDI showed that although the drying trend in summer and winter was weaker than that in spring and autumn in the BLB, where some regions represented a significant tendency toward wetness owing to seasonal or annual changes, the entire study area has still become more dry.