Herpes zoster is associated with an increased dementia and neovascular macular degeneration risk and a decline in glycemic control in diabetes mellitus. Because amyloid is present and pathogenic in these diseases, we quantified amyloid, Aβ40, Aβ42, and amylin in 14 zoster and 10 control plasmas. Compared with controls, zoster plasma had significantly elevated amyloid that correlated with Aβ42 and amylin levels and increased amyloid aggregation with addition of exogenous Aβ42 or amylin. These results suggest that zoster plasma contains factor(s) that promotes aggregation of amyloidogenic peptides, potentially contributing to the toxic amyloid burden and explaining accelerated disease progression following zoster.

中文翻译：

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急性带状疱疹血浆含有升高的淀粉样蛋白，与Aβ42和淀粉样蛋白水平相关，并且是淀粉样蛋白。

带状疱疹与痴呆症和新血管性黄斑变性的风险增加以及糖尿病的血糖控制下降有关。由于存在淀粉样蛋白并在这些疾病中致病，因此我们在14个带状疱疹和10个对照血浆中对淀粉样蛋白，Aβ40，Aβ42和淀粉样蛋白进行了定量。与对照组相比，带状疱疹血浆的淀粉样蛋白显着升高，与Aβ42和淀粉样蛋白水平相关，并通过添加外源性Aβ42或淀粉样蛋白增加淀粉样蛋白聚集。这些结果表明带状疱疹血浆中含有促进淀粉样蛋白生成肽聚集的因子，可能导致毒性淀粉样蛋白负担，并解释带状疱疹后疾病的加速发展。