BAIAP2 might be implicated in neurodevelopmental and psychiatric conditions via abnormal development of human cerebral asymmetry. The present prebirth cohort study examined the relationship between BAIAP2 single nucleotide polymorphism (SNP) rs8079781 and the risk of behavioral problems in Japanese children aged 5 years. Subjects were 1175 mother-child pairs. Emotional problems, conduct problems, hyperactivity problems, peer problems, and low prosocial behavior were assessed using the parent version of the Strengths and Difficulties Questionnaire. Compared with the CC genotype of SNP rs8079781, at least one T allele was significantly inversely related to childhood emotional problems: the adjusted OR was 0.68 (95% CI 0.46-0.998, P = 0.049). Nevertheless, this significant inverse association disappeared after adjustment for multiple comparisons (adjusted P = 0.245). No associations were observed between SNP rs8079781 and childhood conduct problems, hyperactivity problems, peer problems, or low prosocial behavior. An independent positive relationship was observed between smoking in the household during the first year of life and emotional problems in children with the CC genotype, but not in those with at least one T allele (P for interaction = 0.04). This study is the first to show that at least one T allele of SNP rs8079781 was independently associated with a reduced risk of emotional problems in children aged 5 years, but this inverse association fell below significance after adjustment for multiple comparisons. The influence of smoking in the household during the first year of life might rely on rs8079781.

中文翻译：

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BAIAP2 rs8079781，日本 5 岁儿童的产后吸烟暴露和情绪问题：九州冲绳母婴健康研究。

BAIAP2 可能通过人类大脑不对称的异常发育与神经发育和精神疾病有关。目前的产前队列研究检查了 BAIAP2 单核苷酸多态性 (SNP) rs8079781 与日本 5 岁儿童行为问题风险之间的关系。受试者为 1175 对母子。情绪问题、品行问题、多动问题、同伴问题和低亲社会行为使用父母版本的优势和困难问卷进行评估。与 SNP rs8079781 的 CC 基因型相比，至少有一个 T 等位基因与儿童情绪问题显着负相关：调整后的 OR 为 0.68（95% CI 0.46-0.998，P = 0.049）。尽管如此，这种显着的反向关联在调整多重比较后消失（调整后的 P = 0.245）。未观察到 SNP rs8079781 与儿童行为问题、多动问题、同伴问题或低亲社会行为之间存在关联。CC 基因型儿童在出生后第一年的家庭吸烟与情绪问题之间存在独立的正相关关系，但在具有至少一个 T 等位基因的儿童中则没有（交互作用 P = 0.04）。这项研究首次表明，SNP rs8079781 的至少一个 T 等位基因与 5 岁儿童情绪问题风险的降低独立相关，但在调整多重比较后，这种负相关低于显着性。