Nanoemulsion droplets stabilized with a polysaccharide multilayer film were used as carriers for caffeine. Multilayered shells were formed through a subsequent layer-by-layer adsorption of oppositely charged chitosan and alginate (sodium salt) onto emulsion droplets or oil-core nanocapsules at low ionic strength. The hydrophilic positively charged molecules of the drug were impregnated into the film after each alginate layer. The experimental results showed dependence of the encapsulation efficiency of caffeine on the number of the adsorbed polymer layers and on the properties of chitosan used for formation of the film (molecular weight and degree of acetylation). Despite the low encapsulation efficiency of the drug into the capsules (~ 40%) compared with other encapsulation systems, the amount loaded into the film was high enough and pharmacological doses were achieved with very small volumes of the dispersion. Encapsulation of caffeine in polysaccharide multilayered oil-core nanocapsules

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多糖油芯纳米胶囊中咖啡因的包封

用多糖多层膜稳定的纳米乳液液滴用作咖啡因的载体。通过随后在低离子强度下将带相反电荷的壳聚糖和藻酸盐（钠盐）逐层吸附到乳液液滴或油核纳米胶囊上，形成多层壳。在每个藻酸盐层之后，药物的亲水性正电荷分子浸渍到薄膜中。实验结果表明，咖啡因的包封效率取决于吸附的聚合物层数和用于形成薄膜的壳聚糖的性质（分子量和乙酰化程度）。尽管与其他封装系统相比，药物进入胶囊的封装效率较低（约 40%），加载到薄膜中的量足够高，并且以非常小的分散体体积实现了药理学剂量。多糖多层油芯纳米胶囊中咖啡因的包封