Animal models are a significant component of biomedical research and play an important role in translational studies. Traditionally, rodent models have been the mainstay and principal choice of researchers but in recent years, there have been significant changes in the landscape of animal modeling. For example, newer techniques have greatly expanded the use and successful application of large animal models such as pigs for translational studies. The evolving types and species of animal models can influence the research landscape in terms of facilities, expertise, reproducibility and funding streams, which creates new challenges for research studies. It is also important that investigators are prepared to address the necessity of their animal model research and capable to educate the public regarding its value.

中文翻译：

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为转化研究模拟人类疾病面临的不断变化的挑战

动物模型是生物医学研究的重要组成部分，在转化研究中发挥着重要作用。传统上，啮齿动物模型一直是研究人员的中流砥柱和主要选择，但近年来，动物建模领域发生了重大变化。例如，新技术极大地扩展了大型动物模型（例如猪）在转化研究中的应用和成功应用。动物模型的不断发展的类型和物种可以在设施、专业知识、可重复性和资金流方面影响研究领域，这给研究带来了新的挑战。同样重要的是，调查人员准备好解决他们的动物模型研究的必要性，并能够教育公众了解其价值。