WW domain-containing oxidoreductase encoded by the WWOX gene is a transcription regulator and a key player in a number of cellular and biological processes such as tumor suppression, cell proliferation, apoptosis induction, steroid metabolism, and central nervous system development. This review provides a comprehensive summary of currently known roles and discusses the importance of WWOX gene for CNS development and functioning.

中文翻译：

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WWOX基因在大脑发育和病理中。

WWOX基因编码的含WW结构域的氧化还原酶是转录调节剂，并且是许多细胞和生物学过程（例如肿瘤抑制，细胞增殖，凋亡诱导，类固醇代谢和中枢神经系统发育）的关键参与者。这篇综述提供了当前已知作用的全面总结，并讨论了WWOX基因对于中枢神经系统发育和功能的重要性。