PURPOSE We used fractional amplitude of low-frequency fluctuations (fALFF) and gray matter volume (GMV) jointly to explore the mechanism of brain function and structure in unmedicated patients with bipolar disorder (BD). METHODS Thirty first episode drug-naive patients with and thirty healthy controls (HCs) were recruited in this study; All the subjects underwent Magnetic Resonance Imaging (MRI) scanning and performed the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS), all the patients with MDD finished the 17-item Hamilton Depression Rating Scale (HAMD17). Data Processing and Analysis for Brain Imaging (DPABI) and SPM8 were used to find potential differences in fALFF and GMV between the two groups. A Pearson correlation model was used to analyze associations of functional and morphometric changes with clinical symptoms and cognitive tests. RESULTS Compared to healthy controls, the BD group had significantly reduced fALFF values in the lingual gyrus and increased fALFF values in the bilateral superior frontal gyrus and superior frontal gyrus. With regards to VBM, patients with BD showed significant GMV decreases in the bilateral superior temporal gyrus, bilateral superior frontal gyrus, right superior frontal gyrus, right parahippocampal gyrus and precuneus. Additionally, we found an overlap of brain regions focused on the left SFG. Significant negative correlations were observed between abnormal GMV values in the left SFG and vocabulary memory. CONCLUSION The superior frontal gyrus was the site of the most robust and reliable abnormality, with an overlap of abnormal structural and functional MRI features that play an important role in pathology in BD.

中文翻译：

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双相抑郁症患者的低频波动和灰质体积变化的分​​数幅度。

目的我们联合使用低频波动幅度分数（fALFF）和灰质体积（GMV）来探讨双相情感障碍（BD）非药物治疗患者脑功能和结构的机制。方法招募了30名初次使用药物的初治患者和30名健康对照（HCs）。所有受试者均进行了磁共振成像（MRI）扫描，并进行了可重复电池评估神经心理状态（RBANS），所有MDD患者均完成了17个项目的汉密尔顿抑郁量表（HAMD17）。脑成像的数据处理和分析（DPABI）和SPM8用于发现两组之间fALFF和GMV的潜在差异。皮尔逊相关模型用于分析功能和形态变化与临床症状和认知测试的关联。结果与健康对照组相比，BD组舌侧回中的fALFF值明显降低，而双侧上额中回和上额中回的fALFF值增加。关于VBM，BD患者在双侧颞上回，双侧额上回，右上额回，右海马旁回和前突神经的GMV显着下降。此外，我们发现集中在左侧SFG的大脑区域重叠。左SFG的GMV异常值与词汇记忆之间存在显着的负相关。结论额额上回是最坚固，最可靠的异常部位，