Schizophrenia is a severe highly heritable mental disorder. Genetic polymorphisms of dopaminergic pathways are related to pathogenesis of drug response. Hyperprolactinemia (HPRL), a common adverse effect of antipsychotics, is attributed to blockade of dopamine D2 receptors. Ankyrin Repeat and Kinase Domain containing 1 (ANKK1 ) gene is closely related to Dopamine Receptor D2 type (DRD2 ) gene functioning. We examined whether the functional polymorphism rs2734849 in the ANKK1 gene is associated with antipsychotic‐induced HPRL.

中文翻译：

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ANKK1基因多态性与抗精神病药诱发的高泌乳素血症的关联。

精神分裂症是一种严重的高度遗传性精神障碍。多巴胺能途径的遗传多态性与药物反应的发病机制有关。高泌乳素血症（HPRL）是抗精神病药的常见不良反应，归因于多巴胺D2受体的阻滞。包含1（ANKK1）基因的锚蛋白重复和激酶结构域与多巴胺受体D2型（DRD2）基因的功能密切相关。我们检查了ANKK1基因中的功能性多态性rs2734849是否与抗精神病药诱发的HPRL相关。