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Category learning in rodents using touchscreen-based tasks.
Genes, Brain and Behavior ( IF 2.4 ) Pub Date : 2020-05-08 , DOI: 10.1111/gbb.12665
Matthew B Broschard 1 , Jangjin Kim 1 , Bradley C Love 2 , John H Freeman 1
Affiliation  

Categorization is a fundamental cognitive function that organizes our experiences into meaningful “chunks.” This category knowledge can then be generalized to novel stimuli and situations. Multiple clinical populations, including people with Parkinson's disease, amnesia, autism, ADHD and schizophrenia, have impairments in the acquisition and use of categories. Although rodent research is well suited for examining the neural mechanisms underlying cognitive functions, many rodent cognitive tasks have limited translational value. To bridge this gap, we use touchscreens to permit greater flexibility in stimulus presentation and task design, track key dependent measures, and minimize experimenter involvement. Touchscreens offer a valuable tool for creating rodent cognitive tasks that are directly comparable to tasks used with humans. Touchscreen tasks are also readily used with cutting‐edge neuroscientific methods that are difficult to do in humans such as optogenetics, chemogenetics, neurophysiology and calcium imaging (using miniscopes). In this review, we show advantages of touchscreen‐based tasks for studying category learning in rats. We also address multiple factors for consideration when designing category learning tasks, including the limitations of the rodent visual system, experimental design, and analysis strategies.

中文翻译:

使用基于触摸屏的任务在啮齿动物中进行类别学习。

分类是一种基本的认知功能,它将我们的经验组织成有意义的“块”。然后可以将此类别知识推广到新的刺激和情况。多个临床人群,包括患有帕金森病、健忘症、自闭症、多动症和精神分裂症的人,在获取和使用类别方面存在障碍。尽管啮齿动物研究非常适合检查认知功能背后的神经机制,但许多啮齿动物认知任务的转化价值有限。为了弥合这一差距,我们使用触摸屏来允许在刺激演示和任务设计方面具有更大的灵活性,跟踪关键的相关措施,并最大限度地减少实验者的参与。触摸屏为创建啮齿动物的认知任务提供了一个有价值的工具,这些任务可以直接与人类使用的任务相媲美。触摸屏任务也很容易与尖端神经科学方法一起使用,这些方法在人类身上很难做到,例如光遗传学、化学遗传学、神经生理学和钙成像(使用微型显微镜)。在这篇综述中,我们展示了基于触摸屏的任务在研究大鼠类别学习方面的优势。我们还解决了设计类别学习任务时要考虑的多个因素,包括啮齿动物视觉系统的局限性、实验设计和分析策略。
更新日期:2020-05-08
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