Migration‐ and proliferation‐promoting activities in human keratinocytes of Zea mays flower absolute and its chemical composition,Chemistry & Biodiversity

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Migration‐ and proliferation‐promoting activities in human keratinocytes of Zea mays flower absolute and its chemical composition
Chemistry & Biodiversity ( IF 2.3 ) Pub Date : 2020-06-29 , DOI: 10.1002/cbdv.202000227
Do Yoon Kim _{1,

2} , Kyung Jong Won ₃ , Dae Il Hwang _{2,

4} , Ha Bin Kim _{2,

5} , Yali Li ₂ , Hwan Myung Lee ₂

Affiliation

Zea mays L. (ZM) has cytotoxic and anti‐inflammatory activities, but its biological activities such as skin regeneration and wound healing in human skin have not been reported. In the present study, we tested the effects of ZM flower (ZMF) absolute on proliferation and migration of human keratinocytes (HaCaTs) and identified its components by using gas chromatography/mass spectrometry (GC/MS) analysis. GC/MS analysis revealed that the ZMF absolute contained 13 constituents, and it increased HaCaT proliferation and migration. The ZMF absolute enhanced the phosphorylation levels of serine/threonine‐specific protein kinase (Akt), p38 mitogen‐activated protein kinase (MAPK), and extracellular signal‐regulated kinase1/2 in HaCaTs. In addition, the absolute induced an increase in sprout outgrowth of HaCaTs. The present study reports for the first time that ZMF absolute may promote skin wound healing and/or skin regeneration by stimulating proliferative and migratory activities in dermal keratinocytes through the Akt/MAPK pathway. Therefore, ZMF absolute may be a promising natural material for the use in skin regeneration and/or wound healing applications.

中文翻译：

玉米油对人角质形成细胞的迁移和增殖促进活性及其化学成分

Zea mays L. (ZM) 具有细胞毒和抗炎活性，但其在人体皮肤中的皮肤再生和伤口愈合等生物活性尚未见报道。在本研究中，我们测试了 ZM 花 (ZMF) 绝对对人角质形成细胞 (HaCaTs) 增殖和迁移的影响，并通过使用气相色谱/质谱 (GC/MS) 分析鉴定了其成分。GC/MS 分析表明，ZMF 绝对含有 13 种成分，它增加了 HaCaT 的增殖和迁移。ZMF 绝对增强了 HaCaT 中丝氨酸/苏氨酸特异性蛋白激酶 (Akt)、p38 丝裂原活化蛋白激酶 (MAPK) 和细胞外信号调节激酶1/2 的磷酸化水平。此外，绝对值诱导 HaCaTs 的萌芽生长增加。本研究首次报告说，ZMF 绝对可以通过 Akt/MAPK 途径刺激真皮角质形成细胞的增殖和迁移活动，从而促进皮肤伤口愈合和/或皮肤再生。因此，ZMF 绝对可能是一种用于皮肤再生和/或伤口愈合应用的有前途的天然材料。

更新日期：2020-06-29

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