Biological Pincer Complexes,ChemCatChem

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Biological Pincer Complexes
ChemCatChem ( IF 3.8 ) Pub Date : 2020-05-08 , DOI: 10.1002/cctc.202000575
Jorge Nevarez ₁ , Aiko Turmo ₂ , Jian Hu _{1,

2} , Robert P Hausinger _{2,

3}

Affiliation

At least two types of pincer complexes are known to exist in biology. A metal‐pyrroloquinolone quinone (PQQ) cofactor was first identified in bacterial methanol dehydrogenase, and later also found in selected short‐chain alcohol dehydrogenases of other microorganisms. The PQQ‐associated metal can be calcium, magnesium, or a rare earth element depending on the enzyme sequence. Synthesis of this organic ligand requires a series of accessory proteins acting on a small peptide, PqqA. Binding of metal to PQQ yields an ONO‐type pincer complex. More recently, a nickel‐pincer nucleotide (NPN) cofactor was discovered in lactate racemase, LarA. This cofactor derives from nicotinic acid adenine dinucleotide via action of a carboxylase/hydrolase, sulfur transferase, and nickel insertase, resulting in an SCS‐type pincer complex. The NPN cofactor likely occurs in selected other racemases and epimerases of bacteria, archaea, and a few eukaryotes.

中文翻译：

生物钳复合物

已知生物学中至少存在两种类型的钳形复合物。金属-吡咯并喹诺酮醌 (PQQ) 辅因子首先在细菌甲醇脱氢酶中被发现，后来也在其他微生物的选定短链醇脱氢酶中发现。PQQ 相关金属可以是钙、镁或稀土元素，具体取决于酶序列。这种有机配体的合成需要一系列作用于小肽 PqqA 的辅助蛋白。金属与 PQQ 的结合产生 ONO 型钳形复合物。最近，在乳酸消旋酶 LarA 中发现了一种镍钳核苷酸 (NPN) 辅因子。这种辅因子来源于烟酸腺嘌呤二核苷酸，通过羧化酶/水解酶、硫转移酶和镍插入酶的作用，产生 SCS 型钳形复合物。

更新日期：2020-05-08

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