Human cord blood-derived regulatory T-cell therapy modulates the central and peripheral immune response after traumatic brain injury.,STEM CELLS Translational Medicine

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Human cord blood-derived regulatory T-cell therapy modulates the central and peripheral immune response after traumatic brain injury.
STEM CELLS Translational Medicine ( IF 5.4 ) Pub Date : 2020-05-07 , DOI: 10.1002/sctm.19-0444
Henry W Caplan ₁ , Karthik S Prabhakara ₁ , Akshita Kumar ₁ , Naama E Toledano-Furman ₁ , Cecilia Martin ₁ , Louis Carrillo ₁ , Nicolas F Moreno ₁ , Andrea S Bordt ₁ , Scott D Olson ₁ , Charles S Cox ₁

Affiliation

Traumatic brain injury (TBI) causes a profound inflammatory response within the central nervous system and peripheral immune system, which contributes to secondary brain injury and further morbidity and mortality. Preclinical investigations have demonstrated that treatments that downregulate microglia activation and polarize them toward a reparative/anti‐inflammatory phenotype have improved outcomes in preclinical models. However, no therapy to date has translated into proven benefits in human patients. Regulatory T cells (Treg) have been shown to downregulate pathologic immune responses of the innate and adaptive immune system across a variety of pathologies. Furthermore, cellular therapy has been shown to augment host Treg responses in preclinical models; yet, studies investigating the use of Treg as a therapeutic for TBI are lacking. In a rodent TBI model, we demonstrate that human umbilical cord blood Treg modulate the central and peripheral immune response after injury in vitro and in vivo.

中文翻译：

人脐带血来源的调节性 T 细胞疗法可调节脑外伤后的中枢和外周免疫反应。

创伤性脑损伤 (TBI) 会在中枢神经系统和外周免疫系统内引起严重的炎症反应，从而导致继发性脑损伤以及进一步的发病率和死亡率。临床前研究表明，下调小胶质细胞激活并使它们极化为修复/抗炎表型的治疗可以改善临床前模型的结果。然而，迄今为止，还没有一种疗法能够在人类患者身上转化为经证实的益处。调节性 T 细胞 (Treg) 已被证明可以下调先天性和适应性免疫系统在多种病理情况下的病理性免疫反应。此外，在临床前模型中，细胞疗法已被证明可以增强宿主 Treg 反应。然而，目前尚缺乏使用 Treg 治疗 TBI 的研究。在啮齿动物 TBI 模型中，我们证明人脐带血 Treg 在体外和体内损伤后调节中枢和外周免疫反应。

更新日期：2020-05-07

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