Efforts directed toward restoring normal metabolic levels by mimicking the physiological insulin secretion, thereby ensuring safety, efficacy, minimal invasiveness and conveniences, are of great significance in the management of type 1 diabetes among children and adolescents. Regardless of the various technologies being discovered in addressing invasiveness and enhancing medication adherence in the management of type 1 diabetes, yet limited success had been observed among children and adolescents. The multiple daily subcutaneous insulin injections route using vial and syringe, and occasionally insulin pens, remain the most predictable route for insulin administration among children and adolescents. However, this route has been associated with compromised patient compliance, fear of injections and unacceptability, resulting in poor glycemic control, which promote the demand for alternative routes of insulin administration. Alternative routes for delivering insulin are being investigated in children and adolescents with type 1 diabetes; these include the hybrid closed-loop ‘artificial pancreas’ system, oral, inhalation, intranasal routes, and others. This review article explores the current advances in insulin-delivery methods that address the needs of children and adolescents in the treatment of type 1 diabetes.

通过模仿生理胰岛素的分泌来恢复正常的代谢水平，从而确保安全性，有效性，最小的侵袭性和便利性的努力，对于儿童和青少年1型糖尿病的治疗具有重要意义。尽管在治疗1型糖尿病中发现了各种解决侵入性和增强药物依从性的技术，但在儿童和青少年中却观察到有限的成功。每天使用小瓶和注射器进行多次皮下胰岛素注射途径，偶尔使用胰岛素笔仍然是儿童和青少年中最可预测的胰岛素施用途径。但是，此路线与患者依从性受损，对注射的恐惧和不可接受性相关，导致血糖控制不佳，这促进了对胰岛素给药替代途径的需求。正在研究患有1型糖尿病的儿童和青少年中提供胰岛素的替代途径。这些包括混合闭环“人工胰腺”系统，口服，吸入，鼻内途径等。这篇综述文章探讨了胰岛素输送方法的最新进展，这些方法可以满足儿童和青少年在治疗1型糖尿病方面的需求。