From a selection of research topics carried out in our laboratory during the last twenty years it becomes apparent that our main target was the discovery of new or improved synthetic methods together with new properties. Our efforts were made with the aim of being of some utility to other fields of research, with particular emphasis to glycobiology and heterocyle-based bioorganic chemistry. We performed new chemistry mainly in the field of carbohydrate manipulations taking as a primary rule the simplicity and efficiency manners. Toward this end, modern synthetic tools and approaches were employed such as heterocyle-based transformations, multicomponent reactions, organocatalysis, click azide–alkyne cycloadditions, reactions in ionic liquids, click photoinduced thiol-ene coupling, and click sulfur–fluoride exchange chemistry. With these potent methodologies in hand, the syntheses of carbohydrate containing amino acids up to proteins glycosylation were performed. 1 Heterocyclic Glycoconjugates and Amino Acids 2 Triazole-Linked Oligonucleotides: Application of Click CuAAC 3 Non-Natural Glycosyl Amino Acids 4 Non-Natural Oligosaccharides 5 Calixarene-Based Glycoclusters 6 Carbohydrate-Based Building Blocks 7 Homoazasugars and Aza-C-disaccharides 8 Synthesis of Glycodendrimers 9 Peptide and Protein Glycoconjugates 10 Conclusions

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Dondoni 集团近两年（2000-2020）研究课题精选

从过去 20 年在我们实验室进行的一系列研究课题来看，很明显我们的主要目标是发现新的或改进的合成方法以及新特性。我们的努力旨在为其他研究领域提供一些效用，特别强调糖生物学和基于杂环的生物有机化学。我们主要在碳水化合物操作领域进行了新化学，以简单和高效的方式为主要规则。为此，采用了现代合成工具和方法，例如基于杂环的转化、多组分反应、有机催化、点击叠氮化物-炔烃环加成、离子液体中的反应、点击光诱导硫醇-烯偶联和点击硫-氟化物交换化学。有了这些有效的方法，就可以合成含碳水化合物的氨基酸直至蛋白质糖基化。1 杂环糖缀合物和氨基酸 2 三唑连接的寡核苷酸：点击 CuAAC 的应用 3 非天然糖基氨基酸 4 非天然寡糖 5 杯芳烃基糖簇 6 碳水化合物基构建块 7 高氮糖和碳八合二糖合二糖Glycodendrimers 9 肽和蛋白质糖缀合物 10 结论