Rapid Assembly of Oligosaccharides by Using a Hydrophobic Tag-Assisted Liquid-Phase Method,Synlett

当前位置： X-MOL 学术 › Synlett › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Rapid Assembly of Oligosaccharides by Using a Hydrophobic Tag-Assisted Liquid-Phase Method
Synlett ( IF 1.7 ) Pub Date : 2020-05-07 , DOI: 10.1055/s-0040-1707965
Fengting Chu ₁ , Quhao Wei _{2,

3} , Ping Wang ₂ , Dan Lu ₂ , Siyao Wang _{2,

3} , Hongli Yin ₂

Affiliation

A 3,5-didocosyloxybenzyl alcohol tag that was introduced at the anomeric position of the carbohydrate acceptor was applied in the assembly of a pentasaccharide. The intrinsic high solubility in nonpolar solvent and precipitation properties in polar solvent are crucial features of this tag. Thus, rapid and simple precipitation-centrifugation can be conducted throughout the synthetic route at each step to ease work-up and purification processes, and reduce the amount of solvent required. This method provides an efficient, environmental-friendly, and economical approach to synthesize complex oligosaccharides.

中文翻译：

使用疏水标记辅助液相法快速组装寡糖

在碳水化合物受体的异头位置引入的 3,5-二十二烷氧基苄醇标签用于组装五糖。在非极性溶剂中固有的高溶解度和在极性溶剂中的沉淀特性是该标签的关键特征。因此，可以在整个合成路线的每个步骤中进行快速简单的沉淀-离心，以简化后处理和纯化过程，并减少所需的溶剂量。该方法为合成复杂的低聚糖提供了一种高效、环保、经济的方法。

更新日期：2020-05-07

点击分享查看原文

点击收藏

阅读更多本刊最新论文本刊介绍/投稿指南11