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Berry fruits modulate kidney dysfunction and urine metabolome in Dahl salt-sensitive rats.
Free Radical Biology and Medicine ( IF 7.1 ) Pub Date : 2020-05-08 , DOI: 10.1016/j.freeradbiomed.2020.05.002 A Gomes 1 , J Godinho-Pereira 1 , C Oudot 2 , C O Sequeira 3 , A Macià 4 , F Carvalho 5 , M J Motilva 6 , S A Pereira 3 , M Matzapetakis 7 , C Brenner 8 , C N Santos 9
Free Radical Biology and Medicine ( IF 7.1 ) Pub Date : 2020-05-08 , DOI: 10.1016/j.freeradbiomed.2020.05.002 A Gomes 1 , J Godinho-Pereira 1 , C Oudot 2 , C O Sequeira 3 , A Macià 4 , F Carvalho 5 , M J Motilva 6 , S A Pereira 3 , M Matzapetakis 7 , C Brenner 8 , C N Santos 9
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Berries are rich sources of (poly)phenols which have been associated with the prevention of cardiovascular diseases in animal models and in human clinical trials. Recently, a berry enriched diet was reported to decrease blood pressure and attenuate kidney disease progression on Dahl salt-sensitive rats. However, the relationship between kidney function, metabolism and (poly)phenols was not evaluated. We hypothesize that berries promote metabolic alterations concomitantly with an attenuation of the progression of renal disease. For that, kidney and urinary metabolomic changes induced by the berry enriched diet in hypertensive rats (Dahl salt-sensitive) were analyzed using liquid chromatography (UPLC-MS/MS) and 1H NMR techniques. Moreover, physiological and metabolic parameters, and kidney histopathological data were also collected. The severity of the kidney lesions promoted in Dahl rats by a high salt diet was significantly reduced by berries, namely a decrease in sclerotic glomeruli. In addition, was observed a high urinary excretion of metabolites that are indicators of alterations in glycolysis/gluconeogenesis, citrate cycle, and pyruvate metabolism in the salt induced-hypertensive rats, a metabolic profile counteracted by berries consumption. We also provide novel insights that relates (poly)phenols consumption with alterations in cysteine redox pools. Cysteine contribute to the redox signaling that is normally disrupted during kidney disease onset and progression. Our findings provide a vision about the metabolic responses of hypertensive rats to a (poly)phenol enriched diet, which may contribute to the understanding of the beneficial effects of (poly)phenols in salt-induced hypertension.
中文翻译：
浆果可调节Dahl盐敏感性大鼠的肾脏功能障碍和尿代谢组。
浆果是（多）酚的丰富来源，在动物模型和人类临床试验中，它们与预防心血管疾病有关。最近，据报道富含浆果的饮食可以降低Dahl盐敏感性大鼠的血压，并减轻肾脏疾病的进展。但是，未评估肾脏功能，代谢和（多）酚之间的关系。我们假设浆果能促进代谢改变，并伴有肾脏疾病进展的减弱。为此，使用液相色谱（UPLC-MS / MS）和1H NMR技术分析了高血压大鼠（达尔盐敏感性）中富含浆果的饮食所引起的肾脏和尿中代谢组学变化。此外，还收集了生理和代谢参数以及肾脏组织病理学数据。浆果显着降低了高盐饮食在达尔大鼠中引起的肾脏病变的严重程度，即硬化性肾小球的减少。此外，在盐诱导的高血压大鼠中观察到了代谢产物的高尿排泄，这些代谢产物是糖酵解/糖异生，柠檬酸循环和丙酮酸代谢改变的指标，其代谢特征被浆果的摄入所抵消。我们还提供了新颖的见解，将（多）酚的消费与半胱氨酸氧化还原池的变化联系起来。半胱氨酸促成氧化还原信号传导，该信号通常在肾脏疾病发作和发展过程中被破坏。我们的发现为高血压大鼠对富含（多）苯酚的饮食的代谢反应提供了一种设想，
更新日期：2020-05-08
中文翻译：
浆果可调节Dahl盐敏感性大鼠的肾脏功能障碍和尿代谢组。
浆果是（多）酚的丰富来源，在动物模型和人类临床试验中，它们与预防心血管疾病有关。最近，据报道富含浆果的饮食可以降低Dahl盐敏感性大鼠的血压，并减轻肾脏疾病的进展。但是，未评估肾脏功能，代谢和（多）酚之间的关系。我们假设浆果能促进代谢改变，并伴有肾脏疾病进展的减弱。为此，使用液相色谱（UPLC-MS / MS）和1H NMR技术分析了高血压大鼠（达尔盐敏感性）中富含浆果的饮食所引起的肾脏和尿中代谢组学变化。此外，还收集了生理和代谢参数以及肾脏组织病理学数据。浆果显着降低了高盐饮食在达尔大鼠中引起的肾脏病变的严重程度，即硬化性肾小球的减少。此外，在盐诱导的高血压大鼠中观察到了代谢产物的高尿排泄，这些代谢产物是糖酵解/糖异生，柠檬酸循环和丙酮酸代谢改变的指标，其代谢特征被浆果的摄入所抵消。我们还提供了新颖的见解，将（多）酚的消费与半胱氨酸氧化还原池的变化联系起来。半胱氨酸促成氧化还原信号传导，该信号通常在肾脏疾病发作和发展过程中被破坏。我们的发现为高血压大鼠对富含（多）苯酚的饮食的代谢反应提供了一种设想，
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