OBJECTIVES Periodontal disease (PD) and rheumatoid arthritis (RA) are chronic immuno-inflammatory conditions with osteolysis being a hallmark feature. The influence of PD on RA's systemic inflammatory status and disease activity remains unclear. The objective of this study was to assess the systemic inflammation and disease activity of RA under the influence of PD. METHODS In this case-control study, 38 RA patients (19 with PD and 19 without PD) were compared to 38 non-RA patients and 12 healthy controls. Periodontal parameters (bleeding on probing (BOP), probing pocket depth (PPD), PPD Total, PPD Disease and marginal bone loss (MBL) were determined. Serological analyses included quantification of 92 inflammatory biomarkers using a multiplex proximity extension assay, anti-citrullinated protein antibodies (ACPA), rheumatoid factor (IgM-RF) and erythrocyte sedimentation rate (ESR). RA disease activity was determined using Disease Activity Score for 28 joints (DAS28). All RA patients were on medication. RESULTS IgM-RF was higher in RA patients with PD. PD conditions were more severe in the non-RA group. Inflammatory biomarkers (IL-10RB, IL-18, CSF-1, NT-3, TRAIL, PD-L1, LIF-R, SLAMF1, FGF-19, TRANCE, CST5, STAMPB, SIRT2, TWEAK, CX3CL1, CXCL5, MCP-1) were significantly higher in RA patients with PD than RA without PD. DAS28 associated with twice as many inflammatory biomarkers in RA patients with PD whereas IgM-RF and ACPA associated more frequently with biomarkers in the RA without PD group. IgM-RF correlated inversely with BOP. CONCLUSION Periodontal disease augments systemic inflammation in RA. A profound influence exists independent of autoimmune status.

中文翻译：

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类风湿关节炎患者牙周病影响下循环炎症生物标志物的上调

目的 牙周病 (PD) 和类风湿性关节炎 (RA) 是慢性免疫炎症性疾病，骨质溶解是其标志性特征。PD 对 RA 全身炎症状态和疾病活动的影响尚不清楚。本研究的目的是评估 PD 影响下 RA 的全身炎症和疾病活动。方法 在这项病例对照研究中，38 名 RA 患者（19 名患有 PD，19 名没有 PD）与 38 名非 RA 患者和 12 名健康对照者进行了比较。牙周参数（探诊出血 (BOP)、探诊袋深度 (PPD)、PPD Total、PPD 疾病和边缘骨丢失 (MBL)）被确定。血清学分析包括使用多重邻近延伸测定法对 92 种炎症生物标志物进行量化，抗瓜氨酸蛋白质抗体（ACPA），类风湿因子 (IgM-RF) 和红细胞沉降率 (ESR)。使用 28 个关节的疾病活动评分 (DAS28) 确定 RA 疾病活动。所有 RA 患者都在接受药物治疗。结果 患有 PD 的 RA 患者的 IgM-RF 较高。非 RA 组的 PD 情况更严重。炎症生物标志物（IL-10RB、IL-18、CSF-1、NT-3、TRAIL、PD-L1、LIF-R、SLAMF1、FGF-19、TRANCE、CST5、STAMPB、SIRT2、TWEAK、CX3CL1、CXCL5、MCP -1) 在有 PD 的 RA 患者中显着高于没有 PD 的 RA。在患有 PD 的 RA 患者中，DAS28 与两倍的炎症生物标志物相关，而 IgM-RF 和 ACPA 与无 PD 的 RA 组中的生物标志物相关联。IgM-RF 与 BOP 呈负相关。结论 牙周病会增加 RA 的全身炎症。存在独立于自身免疫状态的深远影响。