Oxidative stress results from the imbalances in the development of reactive oxygen species (ROS) and antioxidants defence system resulting in tissue injury. A key issue resulting in the modulation of ROS is that it alters hosts molecular, structural and functional properties which is accomplished via various signalling pathways which either activate or inhibit numerous transcription factors (TFs). Some of the regulators include Nuclear erythroid-2 related factors (Nrf-2), CCAAT/enhancer-binding protein delta (CEBPD), Activator Protein-1 (AP-1), Hypoxia-inducible factor 1(HIF-1), Nuclear factor κB (NF-κB), Specificity Protein-1 (SP-1) and Forkhead Box class O (FoxO) transcription factors. The expression of these transcription factors are dependent upon the stress signal and are sometimes interlinked. They are highly specific having their own regulation cellular events. Depending upon the transcription factors and better knowledge on the type of the oxidative stress help researchers develop safe, novel targets which can serve as efficient therapeutic targets for several disease conditions.

中文翻译：

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细胞信号转导机制中的氧化应激反应转录因子。

氧化应激是由于活性氧 (ROS) 和抗氧化剂防御系统的发育不平衡导致组织损伤。导致 ROS 调节的一个关键问题是它改变了宿主的分子、结构和功能特性，这是通过各种信号通路实现的，这些信号通路激活或抑制了许多转录因子 (TF)。一些调节剂包括核红系 2 相关因子 (Nrf-2)、CCAAT/增强子结合蛋白 delta (CEBPD)、激活蛋白 1 (AP-1)、缺氧诱导因子 1(HIF-1)、核κB 因子 (NF-κB)、特异性蛋白 1 (SP-1) 和 Forkhead Box O 类 (FoxO) 转录因子。这些转录因子的表达取决于应激信号，有时相互关联。它们具有高度的特异性，具有自己的调节细胞事件。根据转录因子和对氧化应激类型的更好了解，研究人员可以开发安全的新型靶标，这些靶标可以作为多种疾病的有效治疗靶标。