Objective

To systematically revise the literature in search of data about the prevalence of constipation in patients with cystic fibrosis according to the publications in this field, which partly refer to guidelines defined in 2010 by the European Society for Pediatric Gastroenterology, Hepatology, and Nutrition.

Sources

Systematic review selecting articles based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses, including Cystic Fibrosis patients of all ages. Sources of information were selected to identify the articles without period limitation: CADTH – Canadian Agency for Drugs and Technologies in Health, CINAHL Complete, Clinical Trials US NIH, Cochrane Library, Embase, MEDLINE via Ovid, Scopus, Web Of Science, PubMed, SciELO, MEDLINE and LILACS , Health Systems Evidence, PDQ Evidence, CRD Canadian Agency for Drugs and Technologies in Health, INAHTA – International Network of Agencies for Health Technology Assessment, and PEDro.

Findings

The prevalence of constipation was reported in eight observational studies. Only two studies assessed the frequency of constipation as a primary objective; in the others, constipation was quoted along with the prevalence of the spectrum of gastrointestinal manifestations. Altogether, the publications included 2,018 patients, the reported prevalence varied from 10% to 57%. Only two of the six articles published after 2010 followed the definition recommended by the European Society.

Conclusions

Constipation is a frequent but still insufficiently assessed complaint of Cystic Fibrosis patients. The use of diverse diagnostic criteria restricts comparison and epidemiological conclusions, future studies should compulsorily apply the European Society for Pediatric Gastroenterology, Hepatology, and Nutrition definition.

中文翻译：

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囊性纤维化患者便秘的患病率：对观察性研究的系统评价。

客观的

根据该领域的出版物系统地修订文献，以搜索有关囊性纤维化患者便秘患病率的数据，这些出版物部分参考了欧洲儿科胃肠病学、肝病学和营养学会于 2010 年定义的指南。

来源

系统评价根据系统评价和荟萃分析的首选报告项目选择文章，包括所有年龄段的囊性纤维化患者。选择信息来源以识别文章，不受期限限制：CADTH – 加拿大健康药物和技术机构、CINAHL Complete、美国 NIH 临床试验、Cochrane 图书馆、Embase、MEDLINE via Ovid、Scopus、Web Of Science、PubMed、SciELO 、MEDLINE 和 LILACS 、卫生系统证据、PDQ 证据、CRD 加拿大卫生药物和技术机构、INAHTA – 国际卫生技术评估机构网络和 PEDro。

发现

八项观察性研究报告了便秘的患病率。只有两项研究将便秘的频率作为主要目标进行了评估；在其他情况下，便秘与胃肠道表现的普遍性一起被引用。这些出版物总共包括 2,018 名患者，报告的患病率从 10% 到 57% 不等。2010 年之后发表的六篇文章中，只有两篇遵循了欧洲学会推荐的定义。

结论

便秘是囊性纤维化患者常见但仍未得到充分评估的主诉。不同诊断标准的使用限制了比较和流行病学结论，未来的研究应强制应用欧洲儿科胃肠病学、肝病学和营养学学会的定义。