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Porous Upconversion Nanostructures as Bimodal Biomedical Imaging Contrast Agents
The Journal of Physical Chemistry C ( IF 3.3 ) Pub Date : 2020-05-08 , DOI: 10.1021/acs.jpcc.0c03945 Ziqing Du 1 , Abhishek Gupta 2 , Christian Clarke 1 , Matt Cappadona 1 , David Clases 3 , Deming Liu 1 , Zhuoqing Yang 4 , Shawan Karan 5 , William S. Price 2 , Xiaoxue Xu 1
The Journal of Physical Chemistry C ( IF 3.3 ) Pub Date : 2020-05-08 , DOI: 10.1021/acs.jpcc.0c03945 Ziqing Du 1 , Abhishek Gupta 2 , Christian Clarke 1 , Matt Cappadona 1 , David Clases 3 , Deming Liu 1 , Zhuoqing Yang 4 , Shawan Karan 5 , William S. Price 2 , Xiaoxue Xu 1
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Lanthanide ion doped upconversion nanoparticles (UCNPs) hold great promise as multimodal contrast agents for a range of medical imaging techniques, including optical bioimaging (OBI), magnetic resonance imaging (MRI), and computed tomography (CT). However, it is challenging to obtain UCNPs with both maximal contrast enhancement effects for both OBI and MRI simultaneously owing to the dilemma in the size of UCNPs. UCNPs in large dimensions contain more photonic Ln ions and less surface defects, which is favored for high luminescent emissions, while small UCNPs with high specific surface areas allow a higher proportion of paramagnetic Ln ions to be more accessible to water molecules, which offers enhanced contrast in MRI. In this work, we report the novel design of core−porous shell UCNPs with both high luminescent emissions and magnetic relaxivities as potential dual-modal contrast agents. The core–porous shell UCNPs were fabricated via the selective etching of the inert shell of NaYF4: 30%Gd at the active core of NaYF4: 20%Yb, 1%Er. Their morphology and composition were carefully characterized using transmission electron microscopy (TEM), energy-dispersive X-ray spectroscopy, X-ray diffraction, and high resolution TEM. Their photoluminescent and magnetic resonance properties were experimentally determined and compared for the core, core–dense shell, and core–porous shell UCNPs. Core–porous shell UCNPs were found to display bright luminescence and superior MRI contrast enhancement, thus showing great potential as bimodal OBI and MRI contrast agents.
中文翻译：
多孔上转换纳米结构作为双峰生物医学成像造影剂。
镧系元素离子掺杂的上转换纳米颗粒（UCNP）作为多峰型造影剂具有广阔的前景，可用于多种医学成像技术，包括光学生物成像（OBI），磁共振成像（MRI）和计算机断层扫描（CT）。然而，由于UCNPs尺寸的困境，同时获得对于OBI和MRI都具有最大对比增强效果的UCNPs是具有挑战性的。较大尺寸的UCNP包含更多的光子Ln离子和较少的表面缺陷，这有利于高发光发射，而具有高比表面积的小型UCNP则使更多比例的顺磁性Ln离子更易与水分子接触，从而增强了对比度在MRI中。在这项工作中 我们报道了具有高发光发射和磁弛豫性的核孔壳UCNPs的新颖设计，作为潜在的双峰型造影剂。通过选择性蚀刻NaYF惰性壳制备核-孔壳UCNPNaYF的活性核心处的4：30％Gd 4：20％Yb，1％Er。使用透射电子显微镜（TEM），能量色散X射线光谱仪，X射线衍射和高分辨率TEM仔细表征了它们的形态和组成。通过实验确定了它们的光致发光和磁共振特性，并比较了核，核致密壳和核-多孔壳UCNP。已发现核孔壳UCNPs表现出明亮的发光和MRI增强的对比度，从而显示出作为双峰OBI和MRI造影剂的巨大潜力。
更新日期：2020-05-08
中文翻译：
多孔上转换纳米结构作为双峰生物医学成像造影剂。
镧系元素离子掺杂的上转换纳米颗粒（UCNP）作为多峰型造影剂具有广阔的前景，可用于多种医学成像技术，包括光学生物成像（OBI），磁共振成像（MRI）和计算机断层扫描（CT）。然而，由于UCNPs尺寸的困境，同时获得对于OBI和MRI都具有最大对比增强效果的UCNPs是具有挑战性的。较大尺寸的UCNP包含更多的光子Ln离子和较少的表面缺陷，这有利于高发光发射，而具有高比表面积的小型UCNP则使更多比例的顺磁性Ln离子更易与水分子接触，从而增强了对比度在MRI中。在这项工作中 我们报道了具有高发光发射和磁弛豫性的核孔壳UCNPs的新颖设计，作为潜在的双峰型造影剂。通过选择性蚀刻NaYF惰性壳制备核-孔壳UCNPNaYF的活性核心处的4：30％Gd 4：20％Yb，1％Er。使用透射电子显微镜（TEM），能量色散X射线光谱仪，X射线衍射和高分辨率TEM仔细表征了它们的形态和组成。通过实验确定了它们的光致发光和磁共振特性，并比较了核，核致密壳和核-多孔壳UCNP。已发现核孔壳UCNPs表现出明亮的发光和MRI增强的对比度，从而显示出作为双峰OBI和MRI造影剂的巨大潜力。
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