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In vivo and in vitro anti-diabetic activity of ethanolic propolis extract.
Journal of Food Biochemistry ( IF 3.5 ) Pub Date : 2020-05-07 , DOI: 10.1111/jfbc.13267 Rabia El Adaouia Taleb 1 , Noureddine Djebli 1 , Hadjer Chenini 1 , Huseyin Sahin 2 , Sevgi Kolayli 3
Journal of Food Biochemistry ( IF 3.5 ) Pub Date : 2020-05-07 , DOI: 10.1111/jfbc.13267 Rabia El Adaouia Taleb 1 , Noureddine Djebli 1 , Hadjer Chenini 1 , Huseyin Sahin 2 , Sevgi Kolayli 3
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The study investigated whether ethanolic propolis extract would exhibit an anti‐diabetic effect in rats. The animals were divided into four groups of five rats each. Diabetic rats received 30% or 15% propolis extract at a dosage of 0.5 ml/100 g for 4 weeks. Data for the diabetic groups treated with 30% and 15% propolis showed a decrease in blood sugar levels from 393 ± 192.7 to 154 ± 28.0 mg/dl and from 386 ± 141.1 to 331.5 ± 123.74 mg/dl, respectively. Compared with the diabetic control group, an improvement was observed in both groups treated with propolis at the pancreatic, hepatic, and renal tissue levels. Antioxidant capacity, phenolic analysis, and the inhibition of α‐amylase and α‐glucosidase were also tested using the propolis samples to support in vivo data. Chrysin and caffeic acid phenyl ester were the dominant phenolics. The IC50 results for α‐amylase (0.62 ± 0.00 μg/ml) and α‐glucosidase (40.40 ± 0.09 μg/ml) were also encouraging.
中文翻译：
乙醇蜂胶提取物的体内和体外抗糖尿病活性。
该研究调查了乙醇蜂胶提取物是否会在大鼠中表现出抗糖尿病作用。将动物分为四组，每组五只大鼠。糖尿病大鼠以0.5 ml / 100 g的剂量接受30％或15％的蜂胶提取物治疗4周。用30％和15％蜂胶治疗的糖尿病组的数据显示血糖水平分别从393±192.7降至154±28.0 mg / dl，从386±141.1降至331.5±123.74 mg / dl。与糖尿病对照组相比，用蜂胶治疗的两组胰腺，肝和肾组织水平均有改善。还使用蜂胶样品测试了抗氧化能力，酚分析以及对α-淀粉酶和α-葡萄糖苷酶的抑制作用以支持体内数据。菊花链和咖啡酸苯酯是主要的酚类化合物。集成电路α-淀粉酶（0.62±0.00μg/ ml）和α-葡萄糖苷酶（40.40±0.09μg/ ml）的50个结果也令人鼓舞。
更新日期：2020-05-07
中文翻译：
乙醇蜂胶提取物的体内和体外抗糖尿病活性。
该研究调查了乙醇蜂胶提取物是否会在大鼠中表现出抗糖尿病作用。将动物分为四组，每组五只大鼠。糖尿病大鼠以0.5 ml / 100 g的剂量接受30％或15％的蜂胶提取物治疗4周。用30％和15％蜂胶治疗的糖尿病组的数据显示血糖水平分别从393±192.7降至154±28.0 mg / dl，从386±141.1降至331.5±123.74 mg / dl。与糖尿病对照组相比，用蜂胶治疗的两组胰腺，肝和肾组织水平均有改善。还使用蜂胶样品测试了抗氧化能力，酚分析以及对α-淀粉酶和α-葡萄糖苷酶的抑制作用以支持体内数据。菊花链和咖啡酸苯酯是主要的酚类化合物。集成电路α-淀粉酶（0.62±0.00μg/ ml）和α-葡萄糖苷酶（40.40±0.09μg/ ml）的50个结果也令人鼓舞。
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