Therapeutic drug monitoring (TDM) of antiepileptic drugs (AEDs) helps optimize drug management for patients with epilepsy. Salivary testing is both noninvasive and easy, and has several other advantages. Due to technical advances, salivary TDM has become feasible for several drugs, including AEDs, and its value has been investigated. Until recently, saliva TDM of perampanel (PER) had not been reported. The purpose of our study was to confirm whether saliva is a biological substitute for plasma in PER TDM.

中文翻译：

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唾液用于吡仑帕奈治疗药物监测的有用性

抗癫痫药物 (AED) 的治疗药物监测 (TDM) 有助于优化癫痫患者的药物管理。唾液检测既无创又简单，还有其他几个优点。由于技术进步，唾液 TDM 已成为包括 AED 在内的几种药物的可行方法，其价值已被研究。直到最近，还没有报道 perampanel (PER) 的唾液 TDM。我们研究的目的是确认唾液是否是 PER TDM 中血浆的生物替代品。