Syncytin‐1: An early marker of immune activation upregulated in multiple sclerosis patients

Marta Garcia‐Montojo, Eulalia Rodriguez‐Martin, Priscila Ramos‐Mozo, Isabel Ortega‐Madueño, Maria Inmaculada Dominguez‐Mozo, Ana Arias‐Leal, Maria Ángel García‐Martínez, Ignacio Casanova, Victoria Galan, Rafael Arroyo, Roberto Álvarez‐Lafuente, Luisa María Villa

Syncytin‐1 is a human protein of retroviral origin that has conserved cell‐cell fusion capabilities. It has been related to multiple sclerosis but its role in cellular immunity and its pathogenic mechanism in the autoimmune context are not fully understood. In this issue, Garcia‐Montojo et al. analyzed the expression of syncytin‐1 in immune cells of multiple sclerosis, infectious patients and controls. The authors found that syncytin‐1 is elevated both in multiple sclerosis and infections and it is an activation marker of monocytes, T‐cells, B‐cells and NKs. Ligation of this membrane protein triggers the activation of antigen presenting cells and the release of pro‐inflammatory cytokines. These results suggest an important role for syncytin‐1 in the activation of leukocytes that is likely contributing to the autoimmune cascade in multiple sclerosis.

https://onlinelibrary.wiley.com/doi/10.1002/eji.201948423

中文翻译：

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期刊综述

Syncytin-1：多发性硬化症患者中免疫激活上调的早期标志物

Marta Garcia‐Montojo，Eulalia Rodriguez‐Martin，Priscila Ramos‐Mozo，Isabel Ortega‐Madueño，Maria Inmaculada Dominguez‐Mozo，Ana Arias‐Leal，MariaÁngelGarcía‐Martínez，Ignacio Casanova，Victoria Galan，RafaelLaroenevar， ，路易莎玛丽亚别墅

Syncytin-1是一种逆转录病毒来源的人类蛋白，具有保守的细胞间融合能力。它与多发性硬化症有关，但在自身免疫环境中其在细胞免疫中的作用及其致病机理尚未完全了解。在本期中，Garcia-Montojo等人。分析了多发性硬化症，感染患者和对照的免疫细胞中合体素-1的表达。作者发现，在多发性硬化症和感染中，syncytin-1均升高，并且它是单核细胞，T细胞，B细胞和NKs的激活标记。这种膜蛋白的连接触发抗原呈递细胞的激活和促炎性细胞因子的释放。

https://onlinelibrary.wiley.com/doi/10.1002/eji.201948423