Peptide aldehyde production: An aldehyde‐releasing reductase (R) domain has been identified as part of a minimal nonribosomal peptide synthetase (NRPS) in X. indica. We also show that the R domain from the tilivalline‐producing NRPS can be used in engineered synthetases to introduce an aldehyde group and subsequently produce natural and unnatural pyrazinones.

中文翻译：

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由具有末端还原酶结构域的最小和工程合成酶生产的非核糖体肽。

肽醛的产生：醛释放还原酶（R）结构域已被确定为X. indica中最小的非核糖体肽合成酶（NRPS）的一部分。我们还表明，从生产蒂罗替林的NRPS中获得的R结构域可用于工程合成酶，以引入一个醛基，随后产生天然和非天然的吡嗪酮。